I have been ANA positive 1:640 on every test since I was 19 - I am now 45. My labs came back yesterday and my ANA was negative! I asked the doctor how that could be after 25 years of positive ANA test and his answer was "they are doing the test differently, a different method of determining and you are negative" .
I would think if this "new" way of doing the test had mine go from positive to negative, that I would not be the only one- it would be lots and lots of people. I can't find anything about it on the internet.

Can a positive ANA become negative? I also just wonder if there was a lab error- the day I went in they were totally understaffed- maybe this isnt even my blood. I am not going to get it redone, because my disease is stable so there it doesnt make any difference if I am positive or not--

just kind of baffled over this news.