Hi there. I'm new to this site. I've been sick for 2 years and was recently diagnosed with Undifferentiated Connective Tissue Disease. Since all of my symptoms are SLE symptoms, they have started me on Plaquenil. Initially my dr. put me on 400 mg. a day, but I was unable to keep food down (terrible diarrhea -sorry to be graphic...ick). He took me off for a few weeks and has now started me back at 200 mg. a day, however it is still giving me a problem with my digestive system. Has anyone else experienced this? I'm wondering if this is something that will just go away with time? I'd like to stay on this medicine if possible, but this is miserable and makes going to work difficult.