You should also know that most Lupus patients suffer from Lupus Headaches. These are just as painful as migraines. However, they DO NOT respond to most migraine medications. They do respond to treatment for the underlying cause (Lupus).
Also, if you have Fibromyalgia, Migraines are a common symptom of this disorder.
I have horrible migraines and Lupus headaches..so I truly symptathize with you.
However, in answer to your question...YES, one of the side effects of Plaquenil can be headaches (known as Plaquenil Headaches) and irritabillity!
Peace and Blessings
Look For The Good and Praise It!