I have, in fact I wrote on your blog before I saw this post. It didn't do much for me with only one pill, but when it did kick in, it was better then Immodium. Your doc is spot on with the drying out effect. When I took Librax I always found myself drinking tons of water that day and the next. I don't take it anymore because I find that a high fiber diet is much better with controlling the IBS then the meds. I still get the cramps when the IBS flares, but I try to work through that with a low residue diet and by managing my stress.