I also react like that to sand flies and even to those giant horse flies!!!! They hurt....itch and make me miserable! I am not sure if that is something caused by Lupus. I know that I do react a little more to mosquito bites now with my Lupus but I have always reacted like this when it comes to flies. Get it checked out and see what the doctor says. For now, I would use some cortisone cream and oral benadryl to help with the swelling and overall yucky feeling of the reaction. Keep us posted on what the good ole doc has to say and please hang in there. I am sending you lots of get well thoughts and soft hugs
As I grow to understand life less and less,
I learn to love it more and more.
Age 29, Lupus for last 7 years
Medications: Methotrexate, Lyrica, Celebrex, Flexeril, Theophylline, Bactrim, Xopenex, Lisinopril, Ultram