Welcome to the forum.
Anti DNA by Farr goes up along with sed rate, C3, C4 numbers will drop reflecting inflammation. My sed rate doubled and I have felt inflammed over the Winter from fibro and joint pain from Lupus although my rhuemy says I'm "okay." I sometimes think the numbers don't reflect what you are really feeling as far as inflammation. My C3 and C4 don't normally drop that much, but my sed rate increases along with my anti-dna.
I don't know if this helps or not. I primarily watch my sed rate and anti-DNA by Farr. Look at the pattern of labs every 3 months and compare. Talk to your doctor and see what he/she says.