I have Lupus and (AIH) Autoimmune Hepatitis. Luckily my AIH is very mild and is controlled well with the drugs I take to keep Lupus under control (100 mg Imuran 7.5 mg of Prednisone and 400 mg of Plaquinel). So far I have been able to avoid a liver biopsy because I was on blood thinners for a blood clot due to APS when they discovered the AIH. By the time I was off the blood thinners, they decided to let me be since I was on the drugs they would use to treat AIH and my liver enzymes had returned to normal.
I believe it is possible for Lupus to affect the liver, however it is usually the one organ that Lupus spares.
Check out this link on Lupus and the liver:
Most people with AIH as opposed to Lupus liver involvement will have a positive ASMA (anti-smooth muscle antibody) as well as a positive ANA. I have both a positive ANA and a positive ASMA. The only AIH message board that I have found is from the UK and currently the sever must be down, but here is the link.