Lymphadenitis is not uncommon with Lupus or with mixed connective tissue disease. It is usually seen when the disease is active and is a frequent sign in systemic lupus erythematosus (SLE). Enlarged lymph nodes are a common symptom in several auto-immune disorders, such as sarcoidosis, systemic lupus erythematosus, & rheumatoid arthritis.
In spite of the fact that LAP usually carries no risk to the patient, SLE patients with LAP usually have higher disease activity levels than SLE patients without LAP. Besides the disease itself, other causes of LAP such as infections, immunological or malignant diseases must be considered when making a differential diagnosis.
Some people exhibit almost constant symptoms of lymphadenitis, which do not resolve, despite treatment. This can be especially true of people with compromised immune systems, such as people with Lupus. People with Lupus are more likely to experience chronic lymphadenitis.
LAP is also the prominent clinical feature of Kikuchi-Fujimoto's disease, which is associated with fever, arthralgia, and leukopenia. These are also symptoms commonly found in SLE.
Since the prognosis and treatment of Kikuchi-Fujimoto's Disease and SLE are different, it is that your doctors differentiate these two diseases.
However, the increased risk of lymphoproliferative diseases (several conditions in which lymphocytes are produced in excessive quantities. They typically occur in patients who have compromised immune systems -In these diseases, cells of the lymphatic system grow excessively. Lymphoproliferative disorders are often treated like cancer) are increased in patients with Lupus. Since there is a considerable overlap between the symptoms of Lupus and the symptoms of lymphoma, it is often difficult to diagnose lymphoma in lupus patients.
What you are describing is not uncommon for Lupus patients, or patients with compromised immune systems. So, you are not alone. While it does indicate that your Lupus is active, it does not necessarily mean that your disease is critical.
Plaquenil is one of the drugs used for lupus that is very well tolerated by most patients. You should not fear its use. You can read through some of the posts here where the drug is described, as well as its side-effects. Lyrica (aka: pregabalin) is used for treating pain, particularly for neuropathic pain and/or seizures. Lyrica is an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Lyrica also affects chemicals in the brain that send pain signals across the nervous system, and so it works for generalized pain also.
You may have thoughts about suicide while taking Lyrica. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
I hope that this information has been helpful to you. Please let us know if you need anything further :lol:
Peace and Blessings