Hi and welcome to the forum. I am sorry that I don't know that much about DLE. I have SLE and I know that the Plaquenil helps me a lot. It does have side affects, but they tend to lessen over time. I am sure that there will be others who will post that may have some answers for you.
Lupus for many years. Like most of my life. Sjogrens that started at 35 and Scoliosis, Spinal Stenosis, Degenerative Disc Disease, Osteo-Arthritis of the spine, Ankylosing Spondilitis, Periferal Neuropathy, mild CP and now just recently diagnosed with PA. I had a disc replaced in December of 2007.
Plaquenil, Sulindac, Imuran, Celiac diet, Tramadol and B12 shot once a month.