Hepatitis C can cause liver cirrhosis and hepatocellular carcinoma. Anti-actin antibodies are generally found in the serum of patients with various forms of chronic cholestatic and non-cholestatic liver disease, and of patients with acute hepatitis B or non-A, non-B, or C. Anti-actin antibody is associated with chronic autoimmune parenchymal liver damage and its appearance may mark the transition from acute hepatitis.
There have been studies on the α-smooth muscle actin (α-SMA) in hepatic stellate cells (HSCs), which are markers of HSC activation, in patients with chronic hepatitis B and hepatitis C. The activation of a-smooth muscle actin directly correlated with necroinflmmatory grades and fibrotic stages in chronic hepatitis B or hepatitis C. Patients with Hepatits C had higher HSC activation than patients with hepatitis A or B.
Autoimmune hepatitis is an inflammation of the liver that is associated with high concentrations of the anti-actin autoantibodies (and other antibodies), To make a definitive diagnosis, doctors must exclude viral causes, hereditary and drug induced liver disease. Autoimmune hepatitis occurs predominantly in women and affects all ages. It is responsible for up to 18% of chronic hepatitis cases not attributable to viruses or alcohol.
I hope I wasn't too clinical in this response. Let me know if you need anything further!
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