The majority of patients find that it may take between 8 to 12 weeks for the disease to respond to Plaquenil. Often you will be given other medications when you start hydroxychloroquine so that you will improve more quickly. Plaquenil is a drug that has to be built up in your body, but one of the attractions of this medication is its long ‘half-life’ – it stays in the system for days & weeks. Many lupus patients find they benefit best from Plaquenil by staying on a ‘long term – low dose regime’.
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