How long pleurisy lasts depends on its cause. For example, pleurisy caused by pleurodynia may come and go over a few days. In rare cases, a person with pleurodynia may have several episodes of pleuritic chest pain over several weeks before the illness finally goes away. In patients with bacterial pneumonia or rheumatic fever, pleurisy typically goes away when the infection is cured with antibiotics. In patients with lung cancer or connective tissue disease (like Lupus), the chest pain of pleurisy may persist for even longer periods.
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