It may mean that you are in a Lupus Flare. The ANA is one indicator used to determine if the disease is active. Almost all people with SLE have a high ANA titer. However, your jump in titer may also indicate that you might have an additional condition. Many conditions may result in a high ANA titer. These conditions include: scleroderma, Sjögren's syndrome, and myositis. Other conditions with a high ANA titer include Raynaud's syndrome, viral infections, and liver disease. Although an ANA titer may help support a diagnosis for these conditions, it is not used by itself to confirm a diagnosis. You should talk to your doctor to see what the jump means to you specifically. A thorough medical history, physical examination, and other tests are needed to confirm any other suspected autoimmune disease.
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