I've been taking DHEA for about 2 years. I can't say that I've seen any improvement, but my condition hasn't become any worse (that is, require any more prednisone to control it), so thats the positive side of it. My doctor thinks it will help alleviate the osteoporosis too. It has "hormonal" side effects - oily skin, acne, and, shall we say, more interest in sex (whereas most drugs we take kill the sex drive!). Nothing I would call masculinization, though.