Morpheus, people with lupus should not use St. Johns Wort. The reason is that it increases photosensitivity, which can be dangerous for people with lupus, who are already photosensitive. St. John's Wort can also interact dangerously with many prescription medications. If you are looking for a something to help with depression, you might want to investigate SAM-e, or the amino acid L-tyrosine, and B-complex vitamin supplements. But be sure to check with your doctor first - any supplement can have contraindications or potential side effects. So it's important for all your health care providers to know about everything you are taking.