Morpheus, have you seen a neurological specialist? Lupus can affect the brain and central nervous system, and it can cause migraine-like headaches and even seizures. So any new, persistent headache in a lupus patient might be a sign of central nervous system involvement. But that really needs to be ruled out by the appropriate tests, like a MRI of the brain, before treatment starts - to be sure it is actually lupus-related. Pain killers just treat the symptoms, not the underlying cause of your headaches. So if you aren't seeing a neurologist yet, I would strongly recommend trying to get in to see one. Or at least talk to your doctor about doing the tests first, rather than just prescribing painkillers and hoping the problem resolves.