The FDA has issued a public health advisory warning about the use of Rituxan after two lupus patients who received Rituxan died of a brain infection called progressive multifocal leukoencephalopathy, or PML. The FDA is urging all doctors to discuss the risk of PML with Rituxan patients. There is no known treatment for PML and it is usually fatal if contracted. Warning symptoms include confusion, dizziness or loss of balance, difficulty talking or walking, and vision problems. Of course, most lupus patients have those anyway as a result of the disease, but any one taking Rituxan should be especially alert. Biogen and Genentech have sent warning letters to doctors - just wanted to make sure all you guys were aware of it too.