I know Plaquenil can make the blood thinner but I am starting to wonder whether I should be concerned. My whole upper arm was bruised from my flu shot, last week I had blood drawn and now have a 3"x3" bruise from that and have had light spotting from my period for 3+ weeks. I am not on Coumadin and do not have APA or lupus anticoagulant. I am on Plaquenil 600 mg a day and Prednisone 5mg a day. No aspirin or Ibuprofen consumption. I am very clutzy so my legs look like I have been fighting Ninjas! Very attractive considering that I have horrid looking Livedo. Any thoughts would be appreciated.