I've been back in the ER with another bout of pericardial effusion (fluid in the sac around the heart.) My doc keeps trying to 'wean' me off prednisone, but everytime I drop down this comes back. This is my fourth trip to the ER (didn't admit me this time, thank God.) I'm on methotrexate which the doc hoped would help me get off steroids. Now I'm back up to 40mg of prednisone a day again. Has anyone experienced recurring pericardial effusion? What's your doc say? Any 'magic' meds that seem to be working? This can be dangerous if it goes on (no kidding) and I'm getting scared. It's been 5 months.....help!