I am providing you with an article about "ANA Negative Lupus" as this condition does, in fact, exist. Your doctor is NOT supposed to use the results of one test to diagnose or not diagnose Lupus. If you ANA is negative, but you have other signs, symptoms, labs, that do suggest Lupus, then you most likely are among those who have ANA Negative Lupus. Here is the article:
In simplest terms, ANA-negative lupus is a condition in which a person’s ANA – or antinuclear anitbody – test comes back negative, but the person exhibits traits consistent with someone diagnosed with lupus. The ANA test is used to screen for lupus, not diagnose it.
Typically, if a person tests positive for the antinuclear antibody, it means only that the person could have lupus. Further tests are needed to determine if a person actually has lupus. Those include tests for Sm (Smith), Ro/SSA (Sjogren's syndrome A), La/SSB (Sjogren's syndrome B), and RNP (ribonucleoprotein) antibodies.But in rare instances, some patients exhibit traits consistent with lupus, specifically these four, which unequivocally diagnose SLE:
- High titer anti-double stranded DNA antibody
- Anti-Sm (Smith) antibody
- Biopsy-proven kidney disease
- Biopsy-proven skin disease
Furthermore, antibody tests and symptoms go hand in hand. Antibodies alone do not diagnose the disease. If you have all four of the above referenced traits, you will, most likely, be diagnosed with SLE. If not all four, than any diagnosis is presumptive. It is presumed the patient has lupus, even if the ANA test comes back negative.
The general consensus is that ANA-negative lupus is not a common occurence. Often doctors will give this name to patients with “lupus-like” disease. Some doctors might call it “mixed connective tissue disease,” “undifferentiated connective tissue disease,” or “forme fruste lupus” – or “hidden lupus”. Each of these, however, has specific and separate meaning and describes different forms of illness.
So, yes, ANA Negative Lupus does exist. However, more importantly is the fact that It is never critical to say definitively that a given patient does or does not have lupus. What is important is to evaluate the current symptoms, to put the symptoms into an overall context that includes blood tests, duration of symptoms, other illnesses, and medications, and to develop a treatment plan based on the total information rather than on a blood test alone.”
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