hi deb, and welcome.
plaquenil does not have a magic date that it starts to take effect.
it works by slowly modifying your body.
it takes an accumulative effect form several doses.
usually it takes about 3 or so months before we realise the effects.
one day you will realise that the pain is less, or the fatigue is less.
you will not put it down to a certain date, but it was a gradual happening
When you're stressed, You eat Ice cream, Cake, Chocolate & Sweets. Why? Because stressed spelled backwards is DESSERTS.