Lupus does not always cause kidney disease, but when it does, kidney involvement can be one of its most significant problems. The kidney problems are due to the production of abnormal autoantibodies. These antibodies are directed against your own tissue, for example, against DNA, the material of which the genes are made. The formation of immune complexes (combinations of these antibodies joining with normal body substances) appears to set up an inflammatory reaction in the kidney.
Several serious clinical disorders can result.
The kidneys are located in the flank (back of the upper abdomen at either side of the spinal column). They are deep within the abdomen and are protected by the spine, lower rib cage, and the strong muscles of the back. This location protects the kidneys from many external forces. They are well-padded for a reason -- kidneys are highly vascular organs, which means that they have a large blood supply. If injury occurs, severe bleeding may result.
Kidneys may be injured by damage to the blood vessels that supply or drain them. This may be in the form of aneurysm, arteriovenous fistula, arterial blockage, or renal vein thrombosis. The extent of bleeding depends on the location and the degree of injury.
Do you have red urine (blood in your urine)?. There is a condition known as Haematuria:
* Haematuria is the presence of red blood cells in the urine.Haematuria may indicate serious underlying problems. There is no clear relationship between the amount of bleeding and the severity of the underlying cause.
* Blood in the urine can come from anywhere in the urinary tract.
* Not all red urine is caused by blood. In any case, you should have your doctor investigate why you are having blood in your urine.
What is haematuria?
Haematuria is the presence of red blood cells in the urine. It can range from obvious bleeding to the microscopic detection of a few red blood cells in a routine urine sample.
When the urine is visibly coloured red by the amount of blood present it is called macroscopic haematuria. Blood that is not visible to the naked eye, but that is apparent on microscopic examination or with a urine test strip is called microscopic haematuria.
Blood in the urine can come from anywhere in the urinary tract: from the kidneys at the top down to the urethra (tube that carries urine from the bladder to the exterior). There is a very long list of possible causes, but infections, stones, tumours or trauma (injury) account for the majority of cases.
There are multiple causes of haematuria, which include the following:
Cancer of the urinary tract (kidney, ureter, bladder, prostate, urethra)
Benign enlargement of the prostate
Infection in the urinary tract
Stones Trauma (including jogging, vigorous exercise)
Rare inflammatory lesions in the urinary tract, including TB, following radiation treatment, interstitial cystitis, and malacoplakia.
Possible causes of bleeding from the upper urinary tract (the kidney) are:
* Kidney stones
o Carcinoma of renal parenchyma ("meat" of the kidney)
o Transitional cell carcinoma of the renal pelvis (cancer of the lining of drainage system of the kidney, see above)
o Angiomyolipoma (a benign tumour of the kidney containing large numbers of blood vessels and fat, prone to spontaneous bleeding)
o Pyogenic infections - which are infections caused by pus forming bacteria
* Congenital (born with) disorders
o Polycystic kidney disease
o Renal cysts
* Bleeding disorders
o Sickle cell disease
o Anticoagulant therapy such as warfarin
* Vascular causes
o Renal emboli (blood clots)
o Renal vein thrombosis
* Interstitial renal disease
o IgA Nephropathy
Ureter (drainage tube of the kidney)
* Trauma (rare in isolation)
* Ureteric stones
* Ureteric tumours (rare)
o Transitional cell carcinoma (cancer of the lining of the ureter).
In any case, as I stated above, you should have your doctor do a complete investigation into the underlying cause of your kidney's painful bleeding.
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