Hi, I'm new and this is my 1st post. I was diagnosed with SLE about a year ago and have been on plaquenil and prednisone tapers. Now rhumatologist wants me to try Methotrexate since my joint pain has worsened. With reluctance I will try it. I'm sure like others, I hope for something to happen positively...like remission! Any comments about the "start up" side effects and on-going use of this med would be beneficial to hear.