My sister tested positive for ANA and for Anti-DS DNA Ab. Her DS DNA Ab is "only" 15, however. The reference range is 0-9, with 5-9 being equivocal and 0-5 as negative. Her doctor apparently repeated the test and it tested positive for DS DNA again at about the same level. She says she has no symptoms but I suspect she may not be being honest, since I know she at least has some fatigue symptoms. She'll be seeing a rheumatologist for the first time next month. So far, it's been her PCP.

What kind of symptoms can you expect at this stage? Her ANA and DS DNA Ab turned positive only this Spring but she was never tested before. If your DS DNA is only in the teens, could you be asymptomatic, only seropositive?

Also, is it true that DS DNA is associated with more serious SLE cases, especially those involving pulmonary and kidney infiltration, than other SLE antibodies like SSA/Ro or SSB/La? I know about Smith and RNP and how they're associated with kidney involvement. But my understanding is that those antibodies usually show up later, i.e., usually after either one of the Sjogren's or DS DNA turn positive.

Also, she's been trying to get pregnant. Which leads me to believe she needs to be tested for anti-phospholipids. I know these are very hasty questions. But do you think it would be preferable for her to get pregnant now, when she has mild symptoms, than wait until her antibodies go up and increase the chance of miscarriage? Thanks for reading these questions, everyone.