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Thread: Dense Fine Speckles ANA pattern

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    Default Dense Fine Speckles ANA pattern

    I have been told that if you are diagnosed with this pattern then all your positive labs mean nothing because this is the pattern of HEALTHY people, regardless of the lab value. Does anyone know anything about this?

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    What you have been told is not accurate. ANA itself is NOT a test for Lupus or any auto immune disease (there isn't a test for Lupus) so many healthy people actually have a positive ANA. positive ANAs often makes GPs send patients to specialists for a further look. There are some NEW studies that suggest that the Nuclear Dense Fine Speckled pattern MAY be a way to weed out healthy patients from people with AI disease if all other testing is normal (meaning if could be a false positive or positive for a different reason). If other testing and symptoms confirm Lupus or other AI diseases then this pattern does not rule it out. It was found to rule it out of 1/3 of patients if memory serves.

    Although more studies need to be done on this it appears to be just like all other testing for Lupus and simply gives clues but no definite answer. Hope this helps
    Last edited by tgal; 06-13-2013 at 01:42 AM.
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    A bit more iinformation. Hope this helps clear things up...

    "It has been reported that up to 20% of healthy people have positive ANA. Interestingly, of these healthy individuals, 33% had specific antibodies directed against the dense fine speckles 70 (DFS70) antigen, which ANA positive patients with a RD usually do not have. Therefore, it can be argued that ANA positive patients with a dense fine speckled pattern have a higher probability of being in good health."

    http://romatizma.dergisi.org/text.php3?id=453
    Mari

    Success is not final, failure is not fatal: it is the courage to continue that counts.

    ~Winston Churchill~







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    Saysusie (07-01-2013)

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    Thank you for the replies and the link....it is making more sense to me now. My ANA pattern seems to change...2 years ago it was homogenous and a few weeks ago it was the DFS pattern. I talked to my Rheum today and she said that with a high ENA/ANA it rules out "healthy false positive". My current labs are:

    ENA/ANA
    NSpl 1:5120 (dense fine speckles) (DFS)

    NSpl includes p80 colin and SP 100
    LEDGF/DFS70

    ENA:

    Sjogren's Syndrome A/Ro 60 Antigen : high positive
    Ro 52 Antigen: high positive
    RNP: high positive
    Smith Antigen: low positive
    Sci-70 (topoisomerase l): low positive

    I also have chronic low white count (CBC)

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    I have a positive ANA with dense fine speckled pattern. They did not do a titre. I also happen to have 15 to 20 of the most common symptoms seen in lupus. Will the DFS ANA result throw my concerns out the window with my doctor?

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