I just started taking Imuran 50 mg yesterday. This is my first real medication for the lupus. I cannot take prednisone or plaquinel due to how it effected my eyes. I have only had 2 doses so far. About an hour after taking the pill I feel so exhausted which is not a bad thing since I have had major insomnia for about 2 years. I am not sure if it is a "side effect" or just me but I am a little itchy - something that is not unusual for me anyway. I guess I will just take some benedryl. Any advice otherwise?