I have not been diagnosed with SLE (just saw a rheumy for the first time) but I did develop ITP (and possibly hemolytic anemia based on a positive coombs test) about 20 years ago. I had a pretty severe case, my platelet count was down to 2K and my hemoglobin was at about an 80. Steroids marginally bumped up my platelets to about 10K so they gave me gammaglobulin a couple of times. Within weeks my counts plummetted so they gave me a splenectomy. I was one of the lucky 60% that it works well for - I haven't had low platelet numbers once over the last 20 years (knock wood). I know splenectomies are not given as often for those with SLE, but it worked well for me 20 years ago when there were fewer treatment options. I hope your husband finds the treatment option that works well for him soon.
This is an ITP forum. Perhaps some folks here can share their experiences or advice with you. http://pdsa.org/forum-sp-534/index.html Best wishes.
Acceptance is the key to happiness.
ITP - 1993
Celiac - 2012
Hashimoto's - 2012