Hello i have stage 5 lupus nephritis and my kidney doctor says he has too treat my condition aggressively. Dued to the fact that I'm on blood thinners for life because of my recent open heart surgery to replace my aortic valve with a mechanical valve and history of blood clot in my heart, lungs and numerous DVTS. Positive lupus anticoagulant. He stated i cant have another biopsy or transplant because my INR drops in less than a second and my blood begins to clot so he says that they only thing that can save my life is having me on 120 mg of prednisone for 12 months tapering off slowly every month little by little until we reach 40 mg. My question is has any one ever been put on a treatment like this for such a long time? If you were was it successful? Ive been on this treatment for about 6 weeks and test results have gotten worse my protein leaking in the urine went from 3495 to almost 5000. Im so scared and confused. Any feedback is highly appreciated.