What meds are you on? For me, it took about two months for me to notice that the Plaquenil was working. And even then, I didn't realize how well it was working until I had to stop it for a while. Because being off it was much worse!
For my pain medication -- amitriptyline -- it took about four days to feel the effect.
You have to be patient and take all this stuff a step at a time. Autoimmune diseases are a long haul-- there's no magic pill to make it all go away, but there are a number of pills that take us steps back in the direction of feeling more normal. But I can say that generally, for most people, the medications will help you feel better in some way.