I have the same problem. At first I thought the plaquenil was making it worse. My Dr. said it was lupus just progressing, and added Imuran. I've been on it for 2 weeks and prednisone. The itching is a little less. I take Benadrly at night along with anti itching creams and Aloe. I have a rash on most of my body and my skin looks sun burnt all over. Does this sound like you? I will say that the rash itches like crazy for a few days, then settles down to an annoying itch, then moves to another body part to start the process again.
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lupus: plaquinil, Imuran, prednisone, vitamin D