My rhuemy and gp together have me on supplements as well as plaquenil and celexa. They help quite a bit. Vitamin D cuz I can't go out in the sun, b12 for energy, fish oil for joints, melatonin for sleep. The fish oil and melatonin are a huge help. My joints still hurt, but are much less stiff with fish oil, and melatonin gives me a great nights sleep with out the nasty side effects of scripts.