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Thread: Anyone take Tramadol/Ultram and an antidepressant?

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    Question Anyone take Tramadol/Ultram and an antidepressant?

    Any antidepressant?

    OR

    In particular, does anyone take the pain med with Welbutrin?

    Also, does anyone by any wild chance take those two in addition to anti-siezure medications? (Topamax and/or Keppra)

    I love being a walking laboratory. Don't you?

    Thanks in advance.

    KCat the Occasional

    P.s. The big blind dog says, "WOOF!" which "ruffly" translates to, "Hello!"
    Last edited by KCat; 02-09-2013 at 09:29 PM. Reason: because I want to

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    I was on tramadol and amitriptyline (a tricyclic antidepressant I use for nerve pain) at the same time for a while. After that, though, you lost me.

    What's your question, though? As I am sure you know, you and your doctor should talk about the risk of seratonin syndrome that comes along with mixing tramadol and antidepressants.

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    You're best bet is to discuss this with your pharmacist. They can help you work out a schedule where the chance of interact does not occur or is lessened. I take tramadol when needed and an anti seizure med and haven't had any problems.

    But it is best to discuss with the pharmacist.

    May good thoughts and God's love flow

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    Quote Originally Posted by Derrie View Post
    I was on tramadol and amitriptyline (a tricyclic antidepressant I use for nerve pain) at the same time for a while. After that, though, you lost me.

    What's your question, though? As I am sure you know, you and your doctor should talk about the risk of seratonin syndrome that comes along with mixing tramadol and antidepressants.
    My question(s) was/were exactly what I asked. I didn't want to know about side effects, interactions, problems, whether or not you had to stop them, etc. Just wanted to know if anyone was on one of these combinations. It's an, "is this even conceivable?" question before I pursue it further. No point in finding a prescribing doc and spending a bunch of money and time on yet another **(&*#$& specialist to hear, "nope, no way, can't be done." The scary stuff online WRT tramadol and AD interactions makes me think that this could be the answer for many anti-depressants because Tramadol has some serotonergic properties. I don't really want to put this decision on a the rheumatologist or GP since I have such a cluster of meds.

    I'm already on the two anti-seizure meds (not for seizures, but for migraine) and tramadol.

    Thanks for your response. Never going on a tricyclic again. Unless I'm having suicidal thoughts which I am not having so...
    Last edited by KCat; 02-10-2013 at 10:10 AM.

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    I have done Celexa,Topamax and Tramadol.

    It did not stop the migraines. I weeded out the Celexa and went up on the Topomax. Still nothing except forgot where I was driving and had electric zap like sensations at night. This was on maybe 1 tramadol 50mg a day not steady pain control type dose.

    I eventually weaned myself from the Topomax as the zaps got worse,headaches no better even without the tramadol.

    During the time I also had to have a lumbar puncture to rule out MS,a brain MRI to check for lesions(that sucked with a migraine I threw up in the parking lot)a nerve conduction because my legs didnt work right and this was before the meds. I finally got the migraines under control with Ambien as mine worsen with loss of sleep and I got in a vicious cycle. WHO can sleep well when you go to bed with and wake up with a headache that makes you feel like your brain is a bad melon.

    If you have any other questions that I can offer experience on I will.

    Hope you find what you are looking for and are able to get the headaches under control.
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    Quote Originally Posted by KCat View Post
    My question(s) was/were exactly what I asked. I didn't want to know about side effects, interactions, problems, whether or not you had to stop them, etc. Just wanted to know if anyone was on one of these combinations. It's an, "is this even conceivable?" question before I pursue it further. No point in finding a prescribing doc and spending a bunch of money and time on yet another **(&*#$& specialist to hear, "nope, no way, can't be done." The scary stuff online WRT tramadol and AD interactions makes me think that this could be the answer for many anti-depressants because Tramadol has some serotonergic properties. I don't really want to put this decision on a the rheumatologist or GP since I have such a cluster of meds.

    I'm already on the two anti-seizure meds (not for seizures, but for migraine) and tramadol.

    Thanks for your response. Never going on a tricyclic again. Unless I'm having suicidal thoughts which I am not having so...
    Okay then, yes, it is conceivable to mix tramadol and an antidepressant. I have also been on carbamazepine (an anti-seizure med used for nerve pain) and tramadol at the same time. Never been on all three.

    Unfortunately, I have no advice for you on finding a doc who will prescribe such a mix. No doctor wants to be on the receiving end of med mal litigation for someone getting a raging case of seratonin syndrome. My docs let me mix a very low dose (100 mg/day max) of tramadol w/ the amitriptyline. We weighed the risks, and it was worth whatever risk there was to attempt to treat my pain.

    Good luck.

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    Quote Originally Posted by Derrie View Post
    Okay then, yes, it is conceivable to mix tramadol and an antidepressant. I have also been on carbamazepine (an anti-seizure med used for nerve pain) and tramadol at the same time. Never been on all three.

    Unfortunately, I have no advice for you on finding a doc who will prescribe such a mix. No doctor wants to be on the receiving end of med mal litigation for someone getting a raging case of seratonin syndrome. My docs let me mix a very low dose (100 mg/day max) of tramadol w/ the amitriptyline. We weighed the risks, and it was worth whatever risk there was to attempt to treat my pain.

    Good luck.
    Thanks much.

    I would dearly love to detox from Tramadol. I really don't even know that it is doing anything for me anymore. I just know that when I skip doses, I go into withdrawal. I'm on 300 mg/day so right there that doesn't bode well for me being allowed to take anything probably. Cripes! I'm so freakin' low and I know it's chemical. But the detox for the tramadol...scary.

    Will just have to see what transpires. I really think Plaquenil is what is keeping me sorted. When I backed off of it about two years ago my pain ramped up despite the tramadol which tells me that really, the tramadol is just an addiction that is of little value right now. And for that matter, preventing me from being able to move on perhaps and get real pain relief when I get breakthrough pain. My migraines are under control. My joint pain is relatively well controlled as long as I stay on the Plaquenil (time for another eye screening) but my mood is plummeting like it did some years back and the only relief then was an AD. Yes, I'm in therapy. I think a lot of this has been triggered by *#($*#*#(& and may I say #*$(&*(#&$#$ING menopause. *#$&*(&#$*&( #*($&(*&#$

    I think I've gotten my feelings across about menopause.

    KCat

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    Quote Originally Posted by ItsLupus2007 View Post
    I have done Celexa,Topamax and Tramadol.

    It did not stop the migraines. I weeded out the Celexa and went up on the Topomax. Still nothing except forgot where I was driving and had electric zap like sensations at night. This was on maybe 1 tramadol 50mg a day not steady pain control type dose.

    I eventually weaned myself from the Topomax as the zaps got worse,headaches no better even without the tramadol.
    I've actually had good luck with the Topamax and no bad side effects - just "tracers" and after-images. No brain freeze or dizzies or anything. I do occasionally get migraines that start during my sleep but they aren't as overwhelming as they used to be. Not the one that make you feel like a bomb has gone off in your head. So that's been good. But I'm on a much higher dose of Tramadol than that so I guess I'm not in good shape for an AD. I was hoping for Welbutrin (to at least try).

    Of course, first I need to check my thyroid - AGAIN! - because that has been flaking out on me for two years and sometimes it's just great and other times it's not and it can't do a hard fail. I don't know if that's gone kaput on me and that's triggering this depression or what. I've put on weight after having lost 20 lbs (back up 14) and just generally feel like the world is crowding in and I'm not able to focus on the things I have to do. I am in the middle of my thesis and this is not a good time to not be able to focus.

    Sorry. Didn't mean to vent but there it is. Thanks for the input. It is helpful. I think I'm outta luck by the sound of it and that's pretty much what I was getting from the "warning labels" I was reading. That bummed me out again last night. For a while I got hopeful that maybe if I saw a psych and got a med I'd get back on track then I remembered about tramadol and Serotonin syndrome and thought, "OHFORCRYINOUTLOUD!" and started crying out loud.

    I think the Tramadol, with it's serotonergic effects has been keeping my depression somewhat at bay for the last ten years and it's just really like taking sugar pills now.

    babble babble babble. Back to writing. Thanks.
    KCat

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    I always want to try tramadol but never sure if it's a good idea because I take carbamazepine and sertraline. I just want better pain relief!
    I spent 2 years travelling Australia. Check out my travel blog at http://travelpod.com/members/helenlear

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    Quote Originally Posted by Shine View Post
    I always want to try tramadol but never sure if it's a good idea because I take carbamazepine and sertraline. I just want better pain relief!
    The issue will be the sertraline. As I said, I take two anti-seizure meds with tramadol. (have to back out an earlier comment. There is some possible reaction with the carbamazepine but I can't determine *what* that reaction is.)

    I think if you can take it "as needed" it may be a decent medication. The doctor that gave it to me umpteen years ago was not terribly well informed and she told me it was not an opiate and said I had to take it daily at x dosage. Well, yes, it does work well if you take it daily. So do all opiates. But you still get addicted to them. I am addicted to Tramadol. I've been on it for at least 12 years. Maybe longer. I can't remember exactly when she gave it to me. 1999 or 2000.

    Anyway. I hate that the drug controls me rather than me controlling the drug. I've never been addicted to anything. I used to smoke cigarettes and I wasn't even addicted to those. I quit overnight. No problem. I'd go days without one then have one just because I wanted one.

    Tramadol is not a classic opiate like Lortab or Oxy, both of which I have taken without becoming addicted and in fact, I don't like them, they make me sick to my stomach so I avoid them if possible. But is an opiate despite what people will tell you. It's just that it works on a very specific receptor, the mu (μ) opioid receptor.

    As Derrie pointed out, the risk is serotonin syndrome. I used to know more about it but I've been out of the medical field for some time. The short version is that both the Sertraline and the Tramadol are serotonergic and taking both can cause an excess of serotonin activity.

    That doesn't mean it isn't feasible. Like was said above, talk to the doc. I'm still going to consult my doc. It may be that I can transition. But do make sure you talk to someone who knows what they're doing. My husband was suggesting I go to my GP and she's a great person but this is not her area of expertise.

    If I had it to do all over again, I would NOT take tramadol daily. But it did get me through a really horrible time until I was able to get to a rheumatologist who got me on Plaquenil and got my illness stabilized. So I guess it happened the way it was supposed to happen.

    Meanwhile, I do hope you get relief. I so understand. Been down that road as we all have. Wish you the best.
    KCat
    Last edited by KCat; 02-10-2013 at 09:45 PM.

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