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Thread: ANA question- new here! ☺

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    Default ANA question- new here! ☺

    Hello! I am new here and I have had health issues for years (I am 41 yrs old)- but always thought they were just odd, random things. To be honest I felt like a hypochondriac when I listed everything I had, so I tended to never follow up on anything, and to not focus on my varying problems. But with my latest symptom being severe Raynauds phenomenon (with ulcers of my toes from it) I couldn't ignore it anymore and with urging from my husband I went to my GP who ran an ANA test, which came back positive 1:640 centromere pattern. She gave me a referral to a Rheumotologist.

    I went to the Rheumotologist yesterday and she was very thorough, spending over an hour with me. She diagnosed me with a connective tissue disease based on my Raynauds, positive ANA, history of low white cells and platelets and joint pain. She also took a ton of blood to look for more specific markers of Lupus or Scelerderma and so I am waiting on those results. She said I have a CT disease, but did not know which one. My symptoms point to Lupus, but she said the centromere pattern of my ANA points more to Scleroderma. Some of my other symptoms I have had are transient elevated liver enzymes, osteopenia, hypothyroidism, debilitating migraines and a history of pre ecplampsia and HELLP syndrome during pregnancies.

    My question is- do any of you have experience with this centromere pattern? Does the ANA pattern hold a lot of weight with the diagnosis? Can it change over time?

    Also can "normal" people have 1:640 ANA's? Is this considered a low postive or high positive?

    Thank you for any input!! I appreciate it! ☺

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    The ANA is a diagnostic tool that helps rheumys who suspect a certain illness to narrow it down.Certain patterns are seen only in certain illnesses.the ANA alone being positive without any other symptoms,labs or markers at a low titer would likely not cause a second glance as it can be found in healthy individuals with no other AI issue.These people dont go on to develop any AI illness and a false positive becomes more common as we age.

    The titer is how many times the collected blood must be diluted until no abnormalities are noted once you get to the point where there are none the last dilution is your number.This is done by DOUBLING the number.

    1st dilution would be 1:40
    2nd dilution would be 1:80
    3rd dilution would be 1:160
    4th dilution would be 1:320
    5th dilution would be 1:640
    6th dilution would be 1:1280
    7th dilution would be 1:2560

    As to the specifics of the centromere I am not familiar with it.I know the ANA can fluctuate,can change pattern as I have been both speckled and homogenous at two different testings.

    The higher the ANA the greater likelihood that there is something AI going on.It sounds like you have a good dr who is listening,waiting to label you until further testing and narrowing of possibilities can be done.You cant really ask for more honestly.

    Hope you find out answers soon and Welcome!
    SLE w/Sjogrens Overlap and Raynaud's diagnosed in 2007.Fibro in 2009.

    The Early Bird May Get The Worm But the Second Mouse Gets The Cheese.

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    Centromere is the reference to the pattern found. It is usually found in CREST and with scleroderma although nothing is set in stone. Below you will find some information on the ANA test from labtestonline.


    http://labtestsonline.org/understand...s/ana/tab/test
    Mari

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    Quote Originally Posted by ItsLupus2007 View Post
    As to the specifics of the centromere I am not familiar with it.I know the ANA can fluctuate,can change pattern as I have been both speckled and homogenous at two different testings.

    The higher the ANA the greater likelihood that there is something AI going on.It sounds like you have a good dr who is listening,waiting to label you until further testing and narrowing of possibilities can be done.You cant really ask for more honestly.

    Hope you find out answers soon and Welcome!
    Thank you for the welcome and your help! I agree, it seems that I have lucked out with a doctor who wants to really investigate and take her time with me. After reading here about so many rheumys who only spend 15 minutes with their patients, I feel blessed. It sounds like my ANA is in the moderate range. Thank you!

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    Quote Originally Posted by tgal View Post
    Centromere is the reference to the pattern found. It is usually found in CREST and with scleroderma although nothing is set in stone.
    Yes that is what I am finding too- that Centromere pattern seems to be found in CREST and Scleroderma. It just seems crazy that I would have a rare disease that only 300,000 people have! I know it can happen, but with the rarity of that syndrome and my symptoms.....I just wonder if this positive ANA centromere pattern I have can still be found in Lupus. Here's hoping that the markers she ran shows something more specific. Thanks for your help!!

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    Hi,

    Just thought I'd reply to your post because I have had the same blood result - 1:640 anticentromere (I also had 1:640 nuclear at the same time). I was diagnosed with lupus because my symptoms point to that rather than scleroderma. Also, that titre is considered high. From what I have read in medical journals it seems rare to have that antibody in lupus, but two different specialists have said it is lupus! Actually I have to go to a new rheumatologist soon and I'm a bit scared that they might decide I don't have lupus after all for this reason. This can be so stressful

    Anyway, I hope you are coping with this diagnosis process okay and I'll be interested to hear how you are diagnosed.

    kindly,

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    Quote Originally Posted by lupuslurker View Post
    Yes that is what I am finding too- that Centromere pattern seems to be found in CREST and Scleroderma. It just seems crazy that I would have a rare disease that only 300,000 people have! I know it can happen, but with the rarity of that syndrome and my symptoms.....I just wonder if this positive ANA centromere pattern I have can still be found in Lupus. Here's hoping that the markers she ran shows something more specific. Thanks for your help!!
    The doctor will take all the information, testing and symptoms) I to account before giving a diagnosis. Since there is no test for lupus the doctor isn't going to say "but the ANA pattern says it can't be Lupus". ANA is simply one tool in leading the way to a diagnoses.
    Mari

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    CREST is a form of Scleroderma its an abbreviation of symptoms.

    This link might help also http://www.clinlabnavigator.com/anti...odies-ana.html
    Last edited by ItsLupus2007; 02-03-2013 at 07:05 PM.
    SLE w/Sjogrens Overlap and Raynaud's diagnosed in 2007.Fibro in 2009.

    The Early Bird May Get The Worm But the Second Mouse Gets The Cheese.

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    Hi Lupuslurker,

    I have had ANA tests come back speckled some times and centromere other times. I have not been diagnoses yet either but my rheumy feels my symptoms are more in line with Lupus than with Scleroderma. She says I have "unspecified connective tissue disease" and feels the symptoms will continue to evolve over time.

    It can be frustrating not to have a clear diagnosis, but as long as you are receiving good treatment for the symptoms it really doesn't matter. My doctor has told me that should I need emergency medical treatment I am to tell them I have lupus to help focus their efforts.

    All the best

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