Hi! I have just been told by my doctor to go off of my Plaquenil that I have taken for 2 and 1/2 years. Reason? Seems I have some macular degeneration going on which I have had since 1997 at least. True, since I began Plaquenil (three months later), I saw a slight increase in symptoms (grey areas just above central vision....noticable when I first wake up and when looking at writing if I concentrate on it) My ANA is 7 1/2 which is almost at protocal remission level. I also have a kidney transplant so I am on Imuran and Neoral (Cyclosporin) for that though at very low levels. He seems to feel I will be ok with the Imuran. Anyone have any situation close to that? It's kind of scary to drop meds for Lupus having had meds for 47 years of some sort. Anyone just take Imuran for their Lupus? Feeling free yet like I'm jumping off a cliff...