I just started Plaquenil this week. I'm taking 200mg twice a day, for a total for 400mg/day. I seem to be tolerating it reasonably well. The only downside is that I feel really nauseated all the time. Per advice given in other threads on this forum, I'm taking it with meals (one pill with breakfast, one with dinner), but I still have a nasty nauseated tummy despite that. I'm not vomiting or anything, but I am pretty uncomfortable. Does anyone know if this will pass, or is this just a rather unpleasant "new normal" I'm going to have to accept if I'm going to be on Plaquenil? I know the drug takes a while to work, and I want to stick with it, but it would be nice if I could look forward to this nausea going away.