Hi I can only give my experience. I have been on planquinl now for just under nine mths. I first felt like a severe case of morning sickness now at 58 I did realise it wasn't that. I found that I must take it with food not even thirty min after it must be with food. As soon as I did that all went well. I did find a slow progression after about two weeks to about six mths of slow continued response and the comparison of pre and post planquinl is: pain went from 10 down to 3; stiffness went from 10 to 2; fatigue went from 8to 2; I have just been through a recent flare up and instead of it lasting for about four months it only lasted 3mths and was controlled with flu like symptoms loss of fine motor cordination, twitching, headache, loss of feeling of heat, loss of smell and taste, stomach not emptying, red spots on skin/blood clots. The whole level of incapacity or degree of effect on my quality of life was at about 4 whereas I would normall be wiped out at 9. So what I am trying to say is I still had a flare but it didn't effect me so badly. So I hope you can tolerate a few of minor side effects that often do wain off and it did for me give me a great deal of relief. Good luck!
For every dark cloud there is a silver lining!
Diagnosed: Lupus; mesenteric panniculitis; fat nacrosis;