I was diagnosed with Drug-Induced Lupus last year after two years of symptoms ranging from Raynaud's to Sjogren's. I was diagnosed by the anti-histone count. We immediately got me off the drug but after a long time my numbers haven't dropped to where they should be already in my doctor's opinion.

My question is: Has anyone ever heard of someone having "real" lupus AND having the anti-histone show up but a negative ANA?

Thanks in advance for any insight.