Hurray for you! Plaquenil takes a while to "get into your system". Be patient - it does help. It also took a while for my body to adjust to it - it gave me "the trots" for a few weeks. I found that I had to ease into it - 1/2 tab for a week or so, then up to a whole tab. My body is so sensitive, I never got past the 1 tab per day, but it is helping.
At least, constipation is never a worry for me while I'm taking Plaquenil - LOL.
Be sure that you go see an ophthalmologist to get a baseline exam done. Very rarely (and usually at much higher doses) Plaquenil can have a bad effect on the retina.
My ophthalmologist sees me every 6 months, and does a thorough test once a year.
Good luck, and I hope that you feel better soon.