I think that a flare can affect ones moods very much so. I know it does me. I am not to sure about by polar though. I can't help but think that depression results from this illness big time. Shoot it is depressing when you hurt all over and other things. Lupus can affect any part of the body at any time.
Lupus for many years. Like most of my life. Sjogrens that started at 35 and Scoliosis, Spinal Stenosis, Degenerative Disc Disease, Osteo-Arthritis of the spine, Ankylosing Spondilitis, Periferal Neuropathy, mild CP and now just recently diagnosed with PA. I had a disc replaced in December of 2007.
Plaquenil, Sulindac, Imuran, Celiac diet, Tramadol and B12 shot once a month.