Lupus and depression. Wow I have had so much depression in my life and just was diagnosed with lupus. I have been hospitalized oh I think 7 times for trying to kill myself because my depression was so bad but about a year ago I saw a energy therapist and in October went off all my medication and have been good depression wise. Yes I have my days I get overwhelmed but not like before. When I found out I had lupus and saw possible effects such as depression, I was releaved.