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    Default Types of Medications

    Medications:
    Main types of drugs
    The main types of drugs used to control lupus include:

    * Steroids
    * Anti-malarials
    * Aspirin
    * Non-steroidal anti-inflammatory drugs (NSAIDs)
    * Immunosuppressants
    * Cytotoxic chemotherapies.

    Steroids
    Steroids (or corticosteroids) are synthetic hormones that mimic the action of cortisone, a naturally occurring hormone produced by the adrenal glands. These drugs are usually taken in tablet form but may be injected in the case of a particularly severe lupus flare. Dosage depends on the severity of symptoms and the person's general state of health, including age and weight. The main function of steroids is to treat inflammation. The flow-on effects of reduced inflammation include reduction of pain and fever. Steroids also dampen the activity of the immune system, which helps to reduce the severity of symptoms. It is very important not to cut back on the dose without your doctor's consent and supervision. Introducing steroids to the body means the adrenal glands reduce production of their own hormones. If the medication is then stopped suddenly, the adrenal glands may not be able to manufacture enough hormones for normal body functions. This dangerous condition is called 'adrenal insufficiency'.

    Side effects of steroids
    Some of the side effects may include:

    * Hair growth abnormalities
    * Increased susceptibility to bruising
    * Increased susceptibility to infections
    * Fluid retention
    * Swollen face
    * Increased appetite
    * Weight gain
    * Thinning of the skin
    * Indigestion, including heartburn
    * Acne
    * Osteoporosis
    * Joint damage (osteonecrosis)
    * Cataracts
    * Stomach ulcers
    * High blood pressure
    * Diabetes mellitus
    * Mood changes and mood swings.

    Anti-malarial drugs
    Anti-malarial drugs were designed to treat malaria, the illness caused by the bite from an infected mosquito. These drugs are also helpful to control the arthritis-like symptoms of joint pain and the sunshine-related skin lesions often associated with lupus. Certain anti-malarial drugs, such as hydroxychloroquine, are used to help alleviate fatigue. However, doses have to be maintained for weeks or even months before an improvement in symptoms occurs. In some cases, anti-malarials allow the person to take a lower dose of steroids.

    Side effects of anti-malarials
    Some of the side effects may include:

    * Nausea
    * Vomiting
    * Diarrhoea
    * Skin rashes
    * Skin colour changes
    * Loss of hair pigment
    * Seizures
    * Eye problems.

    Aspirin
    Aspirin is an effective treatment for the inflammation, pain and fever associated with lupus. Some people can't tolerate aspirin because of its effects on the stomach lining. In these cases, a buffered or coated form of aspirin can be tried. Aspirin should always be taken with food.

    Side effects of aspirin
    Some of the side effects may include:

    * Nausea
    * Vomiting
    * Stomach irritation and bleeding
    * Allergic reaction
    * Thinned blood
    * Greater tendency to bruise.

    Non-steroidal anti-inflammatory drugs (NSAIDs)
    Most people with lupus only need to take non-steroidal anti-inflammatory drugs (NSAIDs) to manage their symptoms. NSAIDs have a similar effect to aspirin. Some people can tolerate them better than aspirin. NSAIDs are used to reduce inflammation, pain and fever associated with lupus. To minimise side effects, NSAIDs should be taken with food, milk or antacids.

    Side effects of NSAIDs
    Some of the side effects may include:

    * Tinnitus (ringing in the ears)
    * Nausea
    * Vomiting
    * Abdominal pain
    * Reduced blood supply to the kidneys
    * Stomach irritation and bleeding.

    Immunosuppressants
    Lupus symptoms are triggered by the abnormal activity of the immune system, the specialised group of cells and chemicals that fight infection. Immunosuppressants reduce lupus symptoms by depressing the immune system. Unfortunately, this leads to an increased susceptibility to infection, because the drugs aren't selective those parts of the immune system that function normally are depressed along with the abnormal parts. Immunosuppressants are very powerful and can provoke a wide range of side effects.

    Side effects of immunosuppressants
    Some of the side effects may include:

    * Increased susceptibility to infections
    * Incompatibility with other drugs
    * Anaemia
    * Low white blood cell count
    * Bone marrow changes
    * Ovarian failure
    * Bleeding from the bladder
    * Slightly increased risk of cancer.

    Cytotoxic chemotherapies
    Cytotoxic chemotherapy is the medical option of last resort; it is used when the person's lupus is severe and all other drugs have failed to control the symptoms. Cytotoxic drugs act on the bone marrow where blood cells are born. A person undergoing this kind of treatment needs to have regular blood tests to make sure they have sufficient blood cells.

    Side effects of cytotoxic chemotherapy
    Some of the side effects may include:

    * Low blood cell counts
    * Increased susceptibility to infections
    * Stomach upsets
    * Nausea
    * Vomiting
    * Hair loss
    * Sterility
    * Slightly increased risk of cancer.

    Medications to avoid
    Lupus medications can interact dangerously with other drugs. Never take drugs for other unrelated conditions unless they are prescribed by the same doctor who treats your lupus. This includes over-the-counter medications that don't require a doctor's prescription. Generally, medications to avoid include:

    * Penicillin
    * Penicillin derivatives
    * Certain epilepsy drugs
    * Any drugs that have prompted a prior allergic reaction.

    Other treatment options
    In addition to medication, other treatments generally recommended for people with lupus include:

    * Limited sun exposure
    * Sunscreen lotions
    * Regular exercise
    * Annual flu vaccinations
    * Regular medical check-ups
    * Healthy, balanced diet
    * Limited alcohol.

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    Default Medications

    I have recently started on cellcept. I tried Immuran and had terrible reaction to it. I have begun feeling similar affects with cellcept. Symptoms are extreme fatigue,Severe depression flu-like symptoms. Have you ever heard of otheres experiencing this from immunosuppressants??

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    Default

    Lgaechter;
    Welcome to our forum :lol: . I have researched your question and have found the following information:
    Cellcept (aka: Mycophenolate Mofetil) is generally used to prevent rejection of an organ. However, as a immunosuppressant, I can see why your doctor would try it for LUPUS. The general side-effects are gastrointestinal upset such as nausea, vomitting and diarrhea. As with most immunosuppressant, common side-effects could include mood swings (euphoria, depression, easy to anger, easy to laugh), increased appetite, weight gain, muscle weakness, joint pain, fragile skin, easy bruising, rounded face and hair growth on the body. Are you also taking Prednisone? It is a cortisteroid and can excacerbate all of the above side-effects!
    You are not going crazy...your emotional reactions are side-effects to the illness and to your drug therapy. You are O.K.!!
    Take Care of Yourself
    Peace and Blessings
    Saysusie

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