Have any of you experienced major weight gain and not be on Med's at the moment?

I eat about one to two times a day and not huge portions. Yet, I have gained so much weight. I am not on Med's for the Lupus at this point as I am trying to hold off as long as I can, and just try to deal with the pain before feeling I have no choice but to go on the med's as the side effects for me I can barely take.