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Thread: Info on Lyrica and Keppra interactions??

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    Question Info on Lyrica and Keppra interactions??

    Hi all. My rheumy and I are discussing pain meds and I mentioned to her Lyrica since I've heard it to have good reviews with patients. I have tried Naprosyn, Neurontin and Cymbalta in the past but have had adverse side effects(GI issues(worsening of GERD and IBS,anxiety/panic attack..)...so she agreed to try a low dose of Lyrica, but we need to make sure it doesn't affect my anti-seizure medication. I'm on 750mgs of Keppra twice a day. Does anyone have any experience and/or knowledge of the 2 meds together? Thanks so much. -Brittanee
    *LadyBug*- Epilepsy Dx: 2003 & UCTD w/SLE features Dx: 2009 SLE/Lupus Dx: May 12th 2011--Current Meds:
    Plaquenil-200mg 2x/day
    Prednisone-7.5mg 1x/day
    Methotrexate- 2.5mg 4 pills 1x/week
    Keppra-750mg 2x/day
    Daily Vitamin-1x/day
    Folic Acid- 1mg 1x/day
    Protonix 40mg 1x/day
    Bentyl- 10mg 4x/day, Miralax- 17g 1x/day
    Vit. D 800IU's 1x/day
    Lyrica- 75mg 1x/day
    Flonase 50mcg 2 sprays each 1x/day

    Wanna know my story, just ask!

    *Lord_Walters_Lady* <3

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    I haven't a clue. I am to the point I am going to have to start pain meds I am afraid (I have refused them so far) and I know many of them will interfere with my seizures meds and I don't want anything that is a narcotic just as a way to protect me from me. I have been clean over 20 years but I really don't want to tempt myself.
    Mari

    Success is not final, failure is not fatal: it is the courage to continue that counts.

    ~Winston Churchill~







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    I'm on keppra and was put on it when it first came on the market i was fully against it but it's a great medication i have no side affects what so ever plus no weight gain which drugs can cause but i don't know about lyrica with it.

    All the best Terri xxx
    Last edited by Peridot20_Gem; 06-02-2011 at 01:22 AM.

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    LYRICA (PREGABALIN) - INFORMATION

    How does it work?

    Lyrica capsules contain the active ingredient pregabalin, which is a medicine that is mainly used to treat epilepsy. It works by stabilising electrical activity in the brain.

    The brain and nerves are made up of many nerve cells that communicate with each other through electrical signals. These signals must be carefully regulated for the brain and nerves to function properly. When abnormally rapid and repetitive electrical signals are released in the brain, the brain becomes over-stimulated and normal function is disturbed. This can result in seizures or fits.

    Pregabalin prevents epileptic fits by preventing the excessive electrical activity in the brain. It does this by mimicking the activity of a neurotransmitter called GABA.

    Neurotransmitters are natural body chemicals that are stored in nerve cells. They are involved in transmitting messages between the nerve cells. GABA is a neurotransmitter that acts as a natural 'nerve calming' agent. It helps keep the nerve activity in the brain in balance. Pregabalin is structurally similar to GABA and so is thought to mimick its action. This helps calm the nerve activity in the brain.

    Pregabalin is used as an add-on treatment for adults whose epilepsy has not been well controlled by other anti-epileptic medicines. It is used to prevent partial seizures, and partial seizures that spread to secondary generalised seizures.

    As pregabalin stabilises electrical nerve activity, it can also be used to treat pain that occurs a result of damage to or a disturbance in the function of nerves (neuropathic pain). It can be used for peripheral neuropathic pain, ie nerve pain in the hands, legs or feet, or central neuropathic pain, eg as a result of a spinal cord injury.

    Pregabalin can also used to treat generalised anxiety disorder.

    What is it used for?
    Epilepsy - used as an add-on therapy for adults with partial seizures with or without secondary generalisation.
    Nerve pain (peripheral and central neuropathic pain) in adults, for example due to diabetic neuropathy, following shingles (post-herpetic neuralgia) or due to spinal cord injury.
    Generalised anxiety disorder in adults.
    Warning!
    This medicine may cause dizziness, sleepiness, confusion or blurred vision and so may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
    This medicine may increase the effects of alcohol.
    There may be a small increased risk of suicidal thoughts and behaviour in people taking antiepileptic medicines such as pregabalin for any condition. For this reason, it is very important to seek medical advice if you, or someone else taking this medicine, experience any changes in mood, distressing thoughts, or feelings about suicide or self-harm at any point while taking this medicine. For more information speak to your doctor or pharmacist.
    This medicine may cause skin reactions. You should let your doctor know if you develop a rash, skin peeling, itching, or other unexplained skin reaction while taking this medicine.
    This medicine may sometimes cause allergic reactions, including angioedema. Consult your doctor immediately if you experience difficulty breathing or swallowing, or swelling of your face, lips, tongue or throat while taking this medicine.
    If you have epilepsy it is important to take your medication regularly, as directed by your doctor, because missing doses can trigger seizures in some people. If you have trouble remembering to take your medicine you should ask your pharmacist for advice. You may find a pill reminder box helpful.
    You should not stop taking this medicine suddenly unless your doctor tells you otherwise, as this may result in your seizures, nerve pain or anxiety returning or getting worse. If it is decided that you should stop taking this medicine, the dose should usually be reduced gradually over at least a week. Follow the instructions given by your doctor.
    Some people have experienced withdrawal symptoms after stopping treatment (long-term or short-term) with this medicine. These have included insomnia, headache, nausea, diarrhoea, flu syndrome, nervousness, depression, pain, sweating and dizziness.

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    kEPPRA (LEVETIRACETAM) - INFORMATION

    How does it work?

    Keppra tablets, oral solution and injection all contain the active ingredient levetiracetam, which is a medicine used to treat epilepsy. It works by stabilising electrical activity in the brain.

    The brain and nerves are made up of many nerve cells that communicate with each other through electrical signals. These signals must be carefully regulated for the brain and nerves to function properly. When abnormally rapid and repetitive electrical signals are released in the brain, it becomes over-stimulated and normal function is disturbed. This results in fits or seizures.

    It is not fully understood how levetiracetam works to control seizures, but its mechanism appears to be different from other antiepileptic medicines.

    Levetiracetam may be used on its own, or as an additional treatment, if other antiepileptic medicines have failed to fully control the epileptic seizures.

    The medicine can be given as a drip into a vein (intravenous infusion) when administration by mouth is not possible.

    What is it used for?
    Partial seizures, with or without secondary generalised seizures in adults and children from one month of age with epilepsy. (Keppra can be used on its own to treat people aged 16 years and over with newly diagnosed epilepsy. In children aged one month and over it should be used as an additional medicine when other antiepileptic medicines have failed to fully control the seizures.)
    Primary generalised tonic-clonic seizures in adults and adolescents from 12 years of age with generalised epilepsy with no known cause (in combination with other treatments).
    Myoclonic seizures in adults and adolescents from 12 years of age with juvenile myoclonic epilepsy (in combination with other treatments).
    Warning!
    This medicine may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
    There may be a small increased risk of depression, suicidal thoughts and behaviour in people taking antiepileptic medicines such as levetiracetam for any condition. For this reason, it is very important to seek medical advice if you, or someone else taking this medicine, experience any changes in mood, distressing thoughts, or feelings about suicide or self-harm at any point while taking this medicine. For more information speak to your doctor or pharmacist.
    If you have epilepsy it is important to take your medication regularly, as directed by your doctor, because missing doses can trigger seizures in some people. If you have trouble remembering to take your medicine you should ask your pharmacist for advice. You may find a pill reminder box helpful.
    You should not stop taking this medicine suddenly unless your doctor tells you otherwise, as this may result in your seizures returning or getting worse. If it is decided that you should stop taking this medicine, it should be withdrawn gradually, according to the instructions given by your doctor.
    Use with caution in
    Children and adolescents (although available data in children do not suggest an impact of this medicine on growth and puberty, long term effects on learning, intelligence, growth, hormone function, puberty and childbearing potential in children remain unknown).
    Decreased kidney function.
    Severely decreased liver function.
    Keppra injection contains sodium, which should be taken into consideration in people on a low sodium diet.
    Not to be used in
    This medicine is not recommended for children under one month of age, as there is insufficient information about its safety and effectiveness in this age group. Keppra tablets are not suitable for children under six months of age. Keppra intravenous infusion is not recommended for children under four years of age.
    Keppra oral solution contains maltitol and is not suitable for patients with rare hereditary problems of fructose intolerance.
    This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

    If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

    Pregnancy and breastfeeding
    Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

    The safety of this medicine for use during pregnancy has not been established. The manufacturer states that it is not recommended for use in pregnancy unless considered essential by your doctor. It is very important for women with epilepsy to talk to the doctor responsible for their epilepsy treatment before becoming pregnant. Stopping antiepileptic treatment during pregnancy runs the risk of the mother having seizures, which can harm both the mother and the foetus. This risk may be higher than that from continuing the medication. It is important that all the risks and benefits of treatment are weighed up. Seek medical advice from your doctor.
    This medicine passes into breast milk. Breastfeeding is not recommended while taking this medicine. Mothers who need to take this medicine should seek medical advice from their doctor.
    Label warnings
    Do not stop taking this medication except on your doctor's advice.
    Side effects
    Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

    Very common (affect more than 1 in 10 people)
    Sleepiness.
    Feeling weak or fatigued.
    Common (affect between 1 in 10 and 1 in 100 people)
    Dizziness or loss of balance.
    Shaky movements and unsteady walk (ataxia).
    Headache.
    Problems with attention or memory.
    Hyperactivity.
    Shaking, usually of the hands (tremor).
    Depression.
    Unstable moods (emotional lability).
    Difficulty sleeping (insomnia).
    Nervousness, agitation.
    Hostility, irritability, aggression.
    Personality disorders.
    Gut disturbances such as abdominal pain, diarrhoea, nausea, vomiting, indigestion.
    Loss of appetite.
    Double or blurred vision.
    Rash or itching.
    Unknown frequency
    Disturbances in the normal numbers of blood cells in the blood.
    Inflammation of the liver or pancreas.
    Hair loss.
    Pins and needles sensations.
    The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

    How can this medicine affect other medicines?
    No significant interactions have so far been reported with this medicine. However, you should tell your doctor what other medicines you are taking before starting treatment with this medicine, and likewise, check with your doctor or pharmacist before taking any new medicines once you have started treatment. This includes medicines bought without a prescription and herbal medicines.

    This medicine does not affect the contraceptive pill.

    It is recommended that people who are taking any antiepileptic medicines should avoid taking the herbal remedy St John's wort (Hypericum perforatum). This is because St John's wort may affect the level of antiepileptic medicines in the blood and could increase the risk of seizures.

    Other medicines containing the same active ingredient
    There are currently no other medicines available in the UK that contain levetiracetam as the active ingredient.

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