HI, I'm newly diagnosed and just started on plaquenil along with prednisone. Yesterday was the first day of plaquenil and I had such a terrible headache all day and my stomach was upset and I know this sounds stupid but my teeth hurt :-). How long does it take to get used to this medicine and should I be watching for any other weird side effects? Is it easier on you to take in the AM or PM or divide the dose in half and take half in the AM and half in the PM. My doc said I could do that if I wanted but yesterday and now today I took both pills together in the AM. Just looking for some answers ...oh I took a sleeping pill last night because the prednisone won't let me sleep and had my first good night's sleep in a while. It helps alot!