Why, with all the meds, do I still hurt?

I have been reading some blogs here and see alot of different things going on. Some people are, like me, have joint pain and fatigue everyday all day. Some people are running marathons. Some people have good days.
Are we all on the same kind of meds? Why is it that I have been taking all these meds (and changing meds) and I find no relief at all. Would I be worst off if I weren't taking any? Do people in remission still take all the meds? And why do they have flare ups with the meds?
I'm just wondering if the meds do anything!

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