View Full Version : Methotrexate question.. feeling icky

09-14-2010, 05:56 PM
I took my first dose of mtx on Sat night and Sunday I was sickly, but I haven't been SOO bad until today. Why today? From what I read on the other mtx thread ppl get sick the day after. Today I'm not hungry, have no energy (less than normal), and I've been freezing all day long with white fingers and toes. I'm usually hot natured, like while others are freezing, I'm usually sweating. I am just so shaky. Has anyone felt this way?
Finally I ate, but my stomach is gurgling and I feel like I can barely hold my head up. I know I need to try. I haven't left the house since Thurs of last week for my docs appt. I mean, I'm in a baaaad way..

09-15-2010, 05:19 AM
You poor thing, I am sorry you have to feel so bad.
I have never taken MTX, so I can't tell you if it is normal to feel this way.
I am sure it is though, at least for most of the people.
I hope you feel much better today.


09-15-2010, 10:59 AM
I'm feeling ten times better today. So that's a good thing. Hopefully it stays this way! Thanks for the reply!

09-18-2010, 10:33 AM
Everyone's reaction time to MTX is different. It is true that many people feel the sickness the day after; my daughter felt it the day of and it lasted for 3-4 days. Since each of our bodies chemical make-up is different, it stands to reason that our reactions to medications might be different too.
I am glad that you are feeling better, now you can probably gauge how long the effects will last and when to expect them.
I wish you the very best!

Peace and Blessings

09-18-2010, 09:24 PM
Yes, I take MTX and I agree that we all react differently. I take my injection on Sunday evening, enjoy some chocolate and some chai tea, and then get to bed. I don't want my husband to even move the bed or I might get sick. Once I get to sleep, I sleep through most of the queasiness.
Monday is my down day. I eat a bland breakfast, usually some rice, and veg out on the couch with the cats all morning. I can't stand much for lunch, maybe some yogurt. By 2 or 3 in the afternoon, I start to feel OK and manage to cook a meal for when Jeff gets home.
I usually feel fairly good the rest of the week, but I'm feeling tired and ready for the next dose by Sunday.
I hope that it helps you!

09-20-2010, 07:49 PM
Thanks for the responses. I have heard several different experiences with this medicine. I took it last night and my back hurts near my kidneys. I have tried to get off of the couch several times only to return to it in defeat. At least I have the option to lay down though. I can't imagine trying to work and take this stuff. By day 3 last week I felt much better, but day one of the meds is harsh for me. I just feel like there are bruises all over my back. I think the fibro is kicking in today. Anyhoo.. back to my Lifetime movie. Thanks yall.

11-16-2010, 04:12 PM
hi isablue,

just checking in with you. i hope you are doing better with the mtx. do you take the pill or injection?

11-16-2010, 05:06 PM
hi isablue we all have different reactions i get sick and nausea and stomach problems end up in bathroom alot have to take stemetil for nausea and buscopan for cramps it just depends on the individual but generally i feel like crap for a couple of days then better. be well kim l

11-17-2010, 05:32 AM
I was on cytoxon for two months and found no bennefit at all, just made me feel worse. doc stopped me on that, wait a week (which I waited three just trying to give my stomach a break) and start the methotrexate, I took dose by mouth for the week on a sunday evening, I expected to feel bad for a couple of days and then start to feel a little better:<( That didn't happen. I felt like !!!CRAP!!! for 5 days strait and then slowly started feeling better. needless to say I did not take a second dose, I don't think the meth is for me.
Isla, I know what you are talking about. I am usually in a t shirt (before lupus) while all others are in sweat shirts. I went through all those symptoms you describe, YUK, could not get warm, no appetite, feel sick and achy, and not to mention fatigued bad! I hope it works out for you. Jim.

12-25-2010, 11:12 PM
I've been taking methotrexate for the past 6 months. When I first started my joint pain would be just as bad as if I were having a flare. At that time I was taking 10mg twice per week. I ended up spreading my 20mg dose over 4 days and found the joint pain went away. I'm back to taking it twice per week now and have no dramas with it. Everyone has a different reaction with it so hopefully you'll get better soon :)