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JohnnyBGood
10-24-2008, 09:07 PM
Hi all,

In earlier posts I mentioned that I had been recently hospitilized due to chest pains...(diagnosis was blood clots in the lung) and that I had been having all sorts of body pains for the longest while (more than 1 year).

After my hospitilization I went to my rheumotologist for a follow up... He ordered a 24-urine test (since I complained that my urine was foamy).... The results say I have too much protein in my urine and have to see a specialist (>5 g/dl)

I just did some limited research on the net and found that Ibuprofen is among some of the drugs that may cause high protein in the urine. Now I had been taking Motrin 2x daily for a good while because I was having much joint pains.

Does anyone have any opinions on this?

Also, would you know if I stop taking the Motrin (which I did) would the protein levels be reversible or did i cause kidney damage?

Thanks.

sits_inthe_corner
10-25-2008, 02:48 AM
Hugs JohnnyBGood

So sorry to hear you are going through this!

I've read several members that have talked about having high protein in their urin.

I remember mention of bubbles in their urin as well. I think it was oluwa.

Those all sound like great questions to get your doctor to answer, and important ones that should be addressed asap.

Hope you are feeling better soon. Flag oluwa down and ask her about this.

I would try to find the post she made on it, but it would be like looking for a needle in a HUGE hay stack. :lol:

Saysusie
10-25-2008, 08:57 PM
Yes, Ibuprofen can cause protein leakage in the urine. In low single doses (200 to 400 mg) and daily doses of up to 1,200 mg, the incidence of adverse side effects is low. However, if you use Ibuprofen on a long-term basis with more than 1,200 mg daily, the chances are greater that you will suffer adverse side effects. Toxic effects are unlikely at doses below 100 mg, but can be severe at doses above 400 mg.

Are you diagnosed with Lupus? If so, the disease can affect the functioning of the kidneys which is detected by protein leakage in the urine. If this is the case, discontinuation of Ibuprofen will be of no avail. It might be wise for your to discuss this with your doctor so that the exact cause can be determined and appropriate treatment can be initiated.

Peace and Blessings
Saysusie

JohnnyBGood
10-26-2008, 08:24 AM
Hi and thanks to you both for your replies and comments.

I do intend to talk to my doctor about this. I didn't already mention it to him because I only discovered this Ibuprofen thing on the internet after I saw him last. So by the time I see him again it will be December and I just wanted to get some opinions from you guys.

I was taking about 800mg a day for at least 6 months.

Yes Saysusie, I have been diagnosed with Lupus in 1999 and I know that it can affect the kidneys... but I never had the issue before and now that it has come up I realized that it could be the NSAIDs I was taking.

By the way, a while ago I did mention to both my Fanily Doctor and my Rheumotologist that I was taking the Motrins, and they both said that it was okay. They never mentioned anything about the protein.

sits_inthe_corner
10-26-2008, 08:52 AM
Glad you are taking this up with your doctors. If your appointment isn't untill december, would it be worth it to call in now, or perhaps go in to see your family doctor?

JohnnyBGood
10-26-2008, 08:59 AM
Yes, I will mention it to my family doctor... but he might not know for sure if it's the Motrin or the Lupus...

The rheumotologist would be better at that... also, I am waiting for an appointment to see a kidney specialist.. so hopefully that doctor will know better with some tests and such.

Saysusie
10-30-2008, 08:13 PM
Please keep us posted!

Peace and Blessings
Saysusie

JohnnyBGood
11-01-2008, 06:51 PM
Well my family doctor doesn't really think that the ibuprofen caused my increase protein levels.

My rheumotologist is referring me to a nephrologist, but I am still waiting for that appointment. In the meantime, he says I can't reduce my prednisone as was originally intended.

But wait...there's more problems now...

This morning I woke up and got out of bed, and my wife notices giant purple patches on the back of both legs... I, of course, got pretty scared. Luckily, my family doctor is open on Saturday and I went straight over there. He says my blood is now too thin (I am on warfarin) and that I somehow bruised myself and caused internal bleeding under the skin. He took soom blood for INR and Liver function tests.. I won't know the results until probably monday... In the meantime, he stopped the warfarin.

He says I shouldn't worry. Should I? This is getting rediculous. I don't know what I will wake up with tomorrow... It seems everyday brings a new surprise.

Saysusie
11-02-2008, 10:53 AM
I'm sorry that you are having so many symptoms and that new ones seem to keep developing. I know it will not make you feel any better, but the truth is that this phenomenon is pretty standard with Lupus :cry:

I'm not sure what your doctor was referring to when he told you not to worry: Was it the cessation of Wafarin? Was it the continuation of Prednisone? Was it the bruises on your legs?

Perhaps he meant that, whatever symptom you woke up with, there is a treatment and/or medication to deal with it. Or perhaps that, whatever they find, it is in the early stages so damage might be minimal and could possibly be reversed.

I would say to you that you should try not to worry too much because STRESS is the #1 culprit in making our symptoms worsen and creating a situation in our bodies that opens itself to new & more serious symptoms. It is imperative that we do all that we can to reduce our stress.

Please let us know the results of your new tests, and please try to find a way to minimize your worry and stress. We are here to help you if you need us!

Peace and Blessings
Saysusie

sits_inthe_corner
11-02-2008, 11:11 AM
Gentle hugs JohnnyBGood

My husband was on warfarin for almost a year after his heart attack and would bruise something awful at the slightest touch.

Stay away from sharp spinny things for a while till that warfarin gets out of your system.

The sever bruising is normal with the warfarin. I'm not sure what happens when it's paired with other medications.

Hubby had to give himself daily injections and would bleed from the needle site all day.

It can take a bit for it to get out of your system so please be careful. By the way hubby is doing really well now.

Glad you are getting some tests and hope you will have some answers soon.

JohnnyBGood
11-02-2008, 11:18 AM
Hi Saysusie,

Thank you so much for being there for me and allowing me to feel that is somewhat "normal" for us.

The doctor was referring to the bruising on my legs in this case.. that I shouldn't worry about it being a major problem.. he says it is my blood being too thin and that I am now prone to easy bruising.

This morning he called me (yes, on a Sunday...wow!) and said my INR was at 3.2... so he reduced my warfarin to 2.0 mg from 4.0 that I was on.

He won't have the liver function results until Tuesday. I am a little worried about that one because I was reading on the internet (again, probably I shouldn't do so much quick research because I tend to let it worry me when I see things)... but anyways, I saw that this kind of bruising could be causes by Cirrhosis which is a whole new game. I asked my doctor about that this morning and he said it wasn't that... but I am not really sure how he knows that 100%.

My wife says the same thing about the stress (but it is quite hard not to worry about it and not know what surprise tomorrow will bring) :(

JohnnyBGood
11-02-2008, 11:21 AM
Gentle hugs JohnnyBGood

My husband was on warfarin for almost a year after his heart attack and would bruise something awful at the slightest touch.

Stay away from sharp spinny things for a while till that warfarin gets out of your system.

The sever bruising is normal with the warfarin. I'm not sure what happens when it's paired with other medications.

Hubby had to give himself daily injections and would bleed from the needle site all day.

It can take a bit for it to get out of your system so please be careful. By the way hubby is doing really well now.

Glad you are getting some tests and hope you will have some answers soon.

The sad part here is that they tell me I am probably going to be on the Warfarin indefinitely.. because of the Lupus and because of the possible hereditariness...

Saysusie
11-02-2008, 03:25 PM
I tend to agree with your doctor about the bruising not being related to Cirrhosis. Many of the causes of Cirrhosis do not fit you. The one that you might remotely be concerned with does not fit your symptomology either. That is autoimmune hepatitis which can cause Cirrhosis...but you do not have autoimmune hepatitis. So, continue to let your doctor regulate the wafarin which is most likely the cause of your bruising and do not overstress yourself with other remote possibilities! At least, try not to overstress yourself. I can't stress (another use of the word lol) how important it is to keep eliminate and/or reduce your stress!!
Almost all of us have to deal with the fact that we never know what we are going to wake up with. The best thing that we can do for ourselves is to take every precaution to hopefully keep flare-ups at bay. So, continue to take good care of yourself and remember, we are here to help you as much as we can :D

Peace and Blessings
Saysusie

sits_inthe_corner
11-02-2008, 04:33 PM
JohnnyBGood

Hopefully they will get you down to a dose that your system can manage better.

If you don't use one already...you might want to switch to an electric razor. Hubby did while he was the Warfarin.

Keep us posted.

JohnnyBGood
11-02-2008, 05:38 PM
Thanks to both of you for your continuing support.

I know I shouldn't stress, but this is all happening very quickly and it is concerning me... I do want to live to see my little boy grow up.

I have been using the electric razor for a while anyways..so that should be okay.

Also, I didn't mention it before, but I also discovered about a year ago that I have Hep B too... I don't know where I got that. So that is also where the liver issues concern me too.

Saysusie
11-02-2008, 09:33 PM
Johnny;
I've lived with Lupus for 28+ years! Nowadays, the chances are very promising that you could live to see your grandchildren get married. Continue to take care of yourself, be vigilant about your health, your medications, your treatment, and about the precautions that we must take in order to maintain some semblance of a healthy lifestyle!

Peace and Blessings
Saysusie

JohnnyBGood
11-05-2008, 08:13 PM
Well just as a follow up for you guys...

Today I went to my appointment for the kidney specialist. Which I wouldn't have had so soon if I didn't step up and call the specialist directly. I was lucky enough to get inserted in a spot that a patient had canceled. My rheumotolost's secretary just kept telling me that I had to wait for an appointment and that she only could speak to the specialist. I proved her wrong!

Anyways, the specialist was a very nice doctor... seemed to geniunely care. Young and attractive too ;)

Anyways, she suspects, based on what I told her and blood/urine results that I have Nephratic Syndrome (yes, yet another problem I have to endure). She wants to do a biopsy, but she says that the fact that I am on the warfarin causes issues. I can't be on it or I may have serious repercussions when performing the biopsy.

She is trying to organize with a surgeon what is the best way to handle this and she is trying to get this done stat, because she thinks my protein (which is at almost 6g/dl) is way too high and needs attention.

So for now, she has given me yet another medicine to take, AVAPRO, which is supposed to protect from kidney disease.

She also requested a kidney ultrasound (which I was lucky enough to have done on the same day) and some more blood/urine tests after a week of taking this new medication.

Saysusie
11-06-2008, 01:19 AM
Hey Johnny;
How are you? Just checking on you to see how the Avapro is working and have you gotten the results of the ultrasound?

Peace and Blessings
Saysusie

JohnnyBGood
11-06-2008, 05:41 AM
Hi Saysusie,

I just started today on the Avapro and I only did the ultrasound yesterday.

I will see the Nephrologist on November 17th for results.

Do you know much about this drug?.. I found out it is also used for high blood pressure... but my blood pressure has been good... will this lower my blood pressure do you think? (I didn't ask the doctor this because when she prescribed it, she said it was to protect the kidneys).

JohnnyBGood
11-06-2008, 01:58 PM
The saga continues...

I just got results of my Kidney ultrasound and they say they found an obstruction... and so I supposedly have something called "Hydronephrosis".

So now they are getting me to see a Urologist urgently.

And they are putting the biopsy on hold until they figure out what to do there.

While I have an appointment in 2 weeks to see a Blood Specialist about the biopsy and warfarin conflict.



Man, this is getting nerve-racking and confusing..... I have a headache and it won't go away

:mad:

KathyW1958
11-06-2008, 02:10 PM
Hi JohnnyBGood,
I am sorry to hear about all the problems that you are having with your kidneys. I will have you in my prayers and hopefully they can get this all cleared up for you.

Hugs,
Kathy

JohnnyBGood
11-06-2008, 02:20 PM
Thank you very much Kathy.

One of the only good things about this whole thing is having met all you good people here who can understand and know what I am going through.

Don't get me wrong, my family is great and very supportive, but sometimes I really wonder if they understand what I am really going through...I guess, on the surface (probably due to the meds) I look fine (a little pale, but fine)... so maybe they don't "see" what is happening underneath the surface.

KathyW1958
11-06-2008, 02:33 PM
Hi JohnnyBGood,
I don't think anyone who does not have this disease can really understand what we go through, because often times we don't look sick. I know my husband tries, but I have to be careful about mentioning to much to him, because he goes into panic mode and gets upset. He gets scared. I think a lot of our family members have a hard time dealing with this illness due to the scare factor and therefore they tend not to talk about it all that much. Maybe when the public becomes more aware of this rotten illness there will be more understanding comming in our direction. Lets hope so anyway. God Bless.

Hugs,
Kathy

sits_inthe_corner
11-06-2008, 05:19 PM
Hey ohnnyBGood

Well I'm glad it sounds like you are finally getting some answers and some action.

Hope things go smoothly for you and you start to feel better very soon. Gentle hugs to ya.

Saysusie
11-06-2008, 10:29 PM
Johnny;
I know it seems like if it ain't one thing its another! I agree with Kathy that no one can have any idea what we go through with this disease and the heinous ways that it attacks our bodies. I'm glad to hear that your doctors are, at least, pro-active. That is a blessing as so many of us do not have that on our sides.
Here is some information about Avapro (aka: Irbesartan plus Hydrochlorothiazide):
Avapro is primarily used for high blood pressure. Avapro HCT contains irbesartan and hydrochlorothiazide. Both medicines reduce blood pressure in different ways. Irbesartan belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin II is a substance produced in the body which causes blood vessels to tighten. Irbesartan blocks angiotensin-II and therefore relaxes your blood vessels. This helps to lower your blood pressure.
Hydrochlorothiazide belongs to the class of medicines known as diuretics. Diuretics cause an increase in the volume of urine. They also help with lowering blood pressure particularly when combined with other blood pressure reducing medicines.
It is especially important that you tell your doctor if you are taking any of the following:
• other tablets for high blood pressure.
• other water tablets or diuretics.
• lithium or lithium-containing medicines (for example Lithicarb®).
• potassium tablets (for example Span-K®, Slow-K®, Mag-K®).
• potassium containing salt substitutes (for example Pressor-K®).
• anti-inflammatory medicines (these are used to relieve pain, swelling and other symptoms of inflammation, including arthritis) and include nonsteroidal anti-inflammatory agents - NSAIDS (for example Voltaren®, Indocid®) and COX-2 inhibitors (for example Celebrex). Taking a combination of Avapro HCT and an anti-inflammatory medicine may damage your kidneys.
• alcoholic drinks
• sleeping tablets
• strong pain killing medicines.
• medicines for diabetes (oral tablets or capsules or insulins)
• calcium supplements, medicines containing calcium or calcium sparing drugs (for example Vitamin D therapy).
• medicines for gout.
• powder or granules used to help reduce cholesterol (Questran Lite or Colestid Granules).
• heart medicines such as digoxin or antiarrhythmic medicines (for example Sotacor®).
• corticosteroid medicines such as prednisone, cortisone or ACTH.
• medicines used to treat cancer (cytotoxic medicines).
• amantadine (Symmetrel), a medicine used to treat Parkinson's disease or to prevent influenza.
• anticholinergic medicines, these can be used to treat Parkinson's disease, to relieve stomach cramps or spasms or used to prevent travel sickness.

Side effects
Avapro HCT helps most people with high blood pressure, but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious. Most of the time they are not.

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Avapro HCT.

Tell your doctor if you notice any of the following and they worry you -

• headache
• dizziness or light-headedness
• unusual tiredness or weakness, fatigue
• pain in the stomach or gut; nausea and/or vomiting
• sexual problems

These are generally mild and do not normally require treatment to be interrupted.

Tell your doctor immediately if you notice any of the following -

• skin rash or itchiness
• aching muscles or aching joints, not caused by exercise
• muscle pain
• buzzing, ringing or other persistent noise in the ears
• changes in heart rhythm
• you are not urinating (passing water) as much as normal
• numbness or tingling in fingers or toes
• painful, swollen joints which may be symptoms of gout
• fainting
• yellowing of the skin and/or eyes, also known as jaundice
• symptoms that may occur if you have developed diabetes, such as excessive thirst, passing greatly increased amounts of urine, increased appetite with weight loss, feeling tired, drowsy, weak, depressed, irritable and generally unwell
• symptoms that may indicate kidney disease such as passing little or no urine, drowsiness, nausea, vomiting, breathlessness, loss of appetite and weakness
• symptoms that may indicate high potassium levels in the blood such as nausea, diarrhoea, muscle weakness and changes in heart rhythm

These are serious side effects. Skin rash and itchiness may be symptoms of an allergic reaction.

You may need medical attention. These side effects are not common.

If any of the following happen, stop taking Avapro HCT and tell your doctor immediately or go to casualty at your nearest hospital -

• swelling to the face, lips, tongue or throat, which may cause difficulty in swallowing or breathing.
• severe and a sudden onset of pinkish, itchy swellings on the skin, also called hives or nettlerash.

These are very rare, but serious side effects. If you have them, you may have a serious allergic reaction to Avapro HCT. You may need urgent medical attention or hospitalization, so contact your doctor or a hospital immediately if you have any of these side effects.

Hope this is helpful.
Peace and Blessings
Saysusie

JohnnyBGood
11-07-2008, 07:27 AM
Thanks guys and thanks Saysusie for the info.

Something I find quirky is why I was even prescribed this Avapro... I need to talk to my family doctor about this.... I wonder if the Nephrologist was just too quick to prescribe something just so she can say she prescribed something.

Basically, until just 3 days before I saw this doctor, my family doctor said my blood pressure was good. The nephrologist told me that I will need a kidney biopsy and then she told me about some of the complications... then she decided to take my blood pressure (which most likely ended up being a little high due to the fact that she just told me about the biopsy and its complications). She even mentioned that she should have taken it prior to telling me that stuff.

So did she over-react in prescribing this Avapro (with this one-time exceptional reading)?! I originally thought she was prescribing a medicine to help with protecting the Kidney.. I am a little confused. I don't want to take meds that are not necessary.... and if my blood pressure is actually normal to start will this med reduce my blood pressure or maintain it?

Saysusie
11-07-2008, 09:37 AM
Johnny;
High Blood Pressure is such a silent and quick killer, I do think that doctors over-react when your reading is high. You may have been under stress at the time of the reading or a medication may have elevated your pressure.
Before you discontinue the drug, do talk to your doctor. Also, do you have a blood pressure machine? Start to take your pressure on a regular basis and keep a log so that you can show it to your doctor at your next visit. You and she can then decide if you need to stop, change or modify your medication.

Peace and Blessings
Saysusie

JohnnyBGood
11-07-2008, 11:35 AM
Also, do you have a blood pressure machine? Start to take your pressure on a regular basis and keep a log so that you can show it to your doctor at your next visit. You and she can then decide if you need to stop, change or modify your medication.

Peace and Blessings
Saysusie

Good idea.. i should look into buying one soon.

JohnnyBGood
11-07-2008, 06:22 PM
I spoke with my family doctor tonight.. he calls me once to twice a week to tell me my INR reading and how to adjust the warfarin I take.

Anyways, I mentioned to him that I was prescribed the Avapro and he said that this is mild drug and that it won't lower my blood pressure to the point of it being too low.. he said it does also protect the kidneys... so he didn't really see it as a bad thing.

Saysusie
11-10-2008, 11:21 PM
I hope that his alleviates some of your concerns :lol: Didja get the BP machine yet?

Peace and Blessings
Saysusie

JohnnyBGood
11-19-2008, 09:29 AM
I saw the nephrologist again a couple of days ago...

She said my kidneys where swollen and is not sure if it is an obstruction causing it... She is sending me to the urologist who she says most like will do a cystography on me to see what's going on. I have an appointment next Tuesday.

About the Avapro... she did a blood pressure check and said it was very good... but she said she more prescribed the medicine to help reduce the protein in my urine.. which based on new results seems to be doing the job for now.

I didn't buy the BP machine yet because it is not cheap and I can't afford it right now.. besides every doctor I have been seeing is checking it and so I really don't need one at the moment, I think. Also, local drugstores here have BP testing stations setup for you to check your own BP..so if I have to I could go there.

Saysusie
11-19-2008, 10:18 PM
Johhny;
I'm glad to hear that the Avapro is working. You are right, if your doctors are taking you BP regularly, you don't need a machine of your own.

Please let us know how your appointment on Tuesday goes! I hope that things continue to work for you.

Peace and Blessings
Saysusie

JohnnyBGood
11-20-2008, 07:34 PM
When it rains... it pours....

Just to add some fun in my life... I now am battling a bout of Conjunctivis (Pink Eye), I suddenly have this major pain in my hip that feels like my hip bone is rubbing against another bone (friction feeling) and can't walk right, and I have a cough that is sometimes so hard to control to the point that it feels like I am choking)..... man... does it ever end.... and oh, my GP still can't get the right dosage of Warfarin... everytime he moves it by 0.5mg, the INR spikes in the opposite direction and out of desired range... so I am a pin cushion at the lab for the last couple of months.

We'll see what fun the urologist adds on Tuesday....

KathyW1958
11-20-2008, 07:47 PM
Hi JohnnyBGood,
Wow I am so sorry to hear about all the bad things happening with you lately. I will have you in my prayers for you to get over all of this horribleness.

Hugs,
Kathy

JohnnyBGood
11-25-2008, 07:04 PM
Well, went to see the Urologist today...

He wants to do a CT scan of my kidneys to see what's causing the hydronephrosis and he wants to to cystography (send a camera up through the bladder and tubes)....

Waiting for an appointment....