View Full Version : Can you guys help?! I'm kind of scared, etc.....ANA Test with my backstory.

07-31-2013, 06:03 PM
I'm new to the forum and don't really know what to think.

Last November I rolled my ankle going down a flight of stairs. At that point I just thought it would heal. About two weeks later I injured it again and left it alone for awhile. When the pain wouldn't stop I went to the foot doctor. He immediately sent me to physical therapy that didn't help, and actually made my knee start hurting...

Fast forward to late May or so and by then both knees and ankles are hurting with some pain in my wrist and jaw as well closer to mid June. During this time I took a few steroids, antibiotics for infection, etc. my husband insisted that the knees and ankles both hurting we're due to my terrible walk and overcompensation from my injured left foot and knee.

In the last month I have taken the steroids for the sore joints and an antibiotic for an infection. Last Monday I went back to the doctor and he did the ana and rheumatoid test.

Tuesday I get a call that the rheumatoid is negative but the ana test is positive measuring 1:1280. On the report it shows that homogeneous, speckled, nucleolar, and centromere. As you probably all know there are different diseases associated with each of these patterns, and I haven't been able to find anyone else that has had 4 patterns show in a test.

Does this mean anything worse? Could there be more than one problem? Could it just be an accident in the test where something was read wrong?

Is 4 patterns rare? Does it sound more like lupus, rheumatoid a, schloederma?

08-05-2013, 11:15 AM
You are correct, the ANA could be associated with so many different diseases. Here is a brief explanation of the patterns in ANA and what conditions they might indicate:

Rim Pattern
Systemic Lupus Erythematosus (http://www.fpnotebook.com/Rheum/Diffuse/SystmcLpsErythmts.htm) (Most Specific)

Homogenous Pattern
Systemic Lupus Erythematosus (http://www.fpnotebook.com/Rheum/Diffuse/SystmcLpsErythmts.htm) (Very specific)
Further evaluation (additional tests)
Anti-dsDNA (http://www.fpnotebook.com/Rheum/Lab/AntDblStrndDnAntbdy.htm)
Anti-ssDNA (http://www.fpnotebook.com/Rheum/Lab/AntSnglStrndDnAntbdy.htm)
Anti-Smith (http://www.fpnotebook.com/Rheum/Lab/AntSmthAntbdy.htm)

Speckled Pattern
Most common, least specific for any particular condition
Possible Disorders
Systemic Lupus Erythematosus (http://www.fpnotebook.com/Rheum/Diffuse/SystmcLpsErythmts.htm)
Mixed Connective Tissue Disease
Scleroderma (http://www.fpnotebook.com/Rheum/Diffuse/SystmcSclrs.htm)
Sjogren's Syndrome (http://www.fpnotebook.com/Rheum/Diffuse/SjgrnsSyndrm.htm)

Further evaluation (additional tests)
Smith Antibody (http://www.fpnotebook.com/Rheum/Lab/AntSmthAntbdy.htm) (Anti-Smith (http://www.fpnotebook.com/Rheum/Lab/AntSmthAntbdy.htm))
Ribonucleoprotein Antibody (http://www.fpnotebook.com/Rheum/Lab/AntRbnclprtnAntbdy.htm) (Anti-RNP (http://www.fpnotebook.com/Rheum/Lab/AntRbnclprtnAntbdy.htm))
Scl-70 kD kinetochore (Anti-Topoisomerase I (http://www.fpnotebook.com/Rheum/Lab/AntTpsmrsIAntbdy.htm))
Anti-La (http://www.fpnotebook.com/Rheum/Lab/AntLAntbdy.htm) (Anti-SSB (http://www.fpnotebook.com/Rheum/Lab/AntLAntbdy.htm))

Nucleolar Pattern
Possible Disorders
Scleroderma (http://www.fpnotebook.com/Rheum/Diffuse/SystmcSclrs.htm)
CREST syndrome

Further evaluation (additional tests)
Scl-70 kD kinetochore (Anti-Topoisomerase I (http://www.fpnotebook.com/Rheum/Lab/AntTpsmrsIAntbdy.htm))

Diffuse Pattern
Non-specific pattern

Centromere Pattern
Seen in PSS with CREST syndrome

We cannot tell you what having four patterns might mean. However, I hope that this gives you a bit of clarification about the various patterns.

Peace and Blessings

08-30-2013, 07:34 AM
Might be Mixed Connective Disease where you have multiple disease pattern. Thats what I was diagnosed with!