View Full Version : Confused by ANA pattern???

05-29-2012, 06:14 PM
I have yet to be diagnosed, but I have been referred to a rheumy because of a variety of symptoms and my ANA test results. My titer is 1:160, and my pattern is homogeneous and speckled. The pattern confuses me. I don't find anything that shows those two can occur simultaneously. Everything I find shows either homogeneous or speckled. Can anyone shed some light on this for me? It will be three weeks before I go to the rheumy. The fear of the unknown is terrible.

05-29-2012, 09:08 PM
I'm not great at understanding the pattern stuff either, but I think that I've read that speckled is common for Lupus patients.
I'm sure that Mari or SaySusie will have that info at their fingertips.

05-30-2012, 02:02 AM
The patterns are simply used to point doctors in the right direction. It is possible to have both kinds in one test. A brief description follows:

What the pattern means:
Rim / Peripheral - found almost exclusively in people with SLE (http://cure4lupus.org/store/index.php?main_page=page&id=195&chapter=1)
Homogenous / Smooth - found in high titers in SLE (http://cure4lupus.org/store/index.php?main_page=page&id=195&chapter=1) also found in Drug-Induced Lupus (http://cure4lupus.org/store/index.php?main_page=page&id=158&chapter=1), and other autoimmune (http://cure4lupus.org/store/index.php?main_page=page&id=163&chapter=1#autoimmune) diseases, also the most commonly found pattern in healthy individuals
Speckled - found in SLE (http://cure4lupus.org/store/index.php?main_page=page&id=195&chapter=1), mixed connective tissue disease, Sjogren's Syndrome (http://cure4lupus.org/store/index.php?main_page=page&id=15&chapter=6#sjogrens), Scleroderma (http://cure4lupus.org/store/index.php?main_page=page&id=15&chapter=6#sclero)
Diffuse - non-specific pattern
Nucleolar - found in Scleroderma (http://cure4lupus.org/store/index.php?main_page=page&id=15&chapter=6#sclero), CREST Syndrome, systemic sclerosis, and sometimes SLE (http://cure4lupus.org/store/index.php?main_page=page&id=195&chapter=1) or Rheumatoid Arthritis (http://cure4lupus.org/store/index.php?main_page=page&id=15&chapter=6#ra)
Centromere - found in PSS with CREST Syndrome, polymyositis, Raynaud's Syndrome

Mixed patterns are actually quite common in Lupus patients, especially since many have overlapping diseases. The good news is that many of the AI diseases are treated basically the same way so it is nothing to freak out about.

06-23-2012, 04:39 PM
Since my diagnosis, I think the only patterns I've had have been homogenous and speckled but I wouldn't swear to it. I'm going to check out some of my old lab reports and see if I've had any different ones. My titer has been as high as 1280 and was actually negative for a few years. The latest was 1:640 a couple of weeks ago. Not sure if that helps :-)

06-23-2012, 04:46 PM
Many doctors will only check your ANA once if it comes out positive. Good doctors know that the ANA will go back and forth between positive and negative as well as change in patterns. Change in ANA is very normal even in active Lupus