View Full Version : An answer or just more questions?
05-02-2006, 09:05 PM
I don't know if this goes here or not... BUT, I didn't know where else to put it... So, on the never-ending search of "why do I have Lupus?" my mother and I were talking... She has a condition where she is not immune to childhood diseases such as chicken pox, mumps, measels, etc... No matter how many times she gets them, and no matter how many vaccinations she gets... Sounds like and auto-immune disorder to me...
So, I am wondering... A. Has anyone ever heard of this condition, or is my mother just a freak? B. IS it autoimmune related? And C. If you know the answers to any of these questions, is it possible that this is where my Lupus came from?
05-03-2006, 10:02 AM
I am now 30 years old, and in that 30 years I have had both the chickenpox AND the measles TWICE. Until now, I have not heard of anyone else this has happened to. I still don't have a definite diagnosis of lupus, but it is ineveitable at this point. I have also suffered from varying illnesses and unexplained rashes for as long as I can remember. It certainly sounds suspicious, doesn't it? Does your mother have any other ailments that could be related to lupus? I have had 3 rounds of immunizations now because each doctor said I could have received a non-effective batch...what are the chances? Not to rule out the theory that your mom could be a freak, because I have had the same thoughts. :lol: At least you now know she isn't alone...should we start a parade?!?
05-04-2006, 01:45 AM
The consensus is that Lupus, while not directly inheritable, does seem to have an indirect genetic link. Doctors believe that the tendancy to develop lupus may be inherited. However, inheriting a genetic tendancy does not mean you will develop the disease. It's theorized that environmental triggers must occur in someone predisposed, in order for lupus to develop.
Here is an article I found written by Raphael J. DeHoratius, MD:
The most frequently asked question about lupus is, "Is lupus inherited?" The answer to this question is both "yes" and "no"! Genes, those parts of our individual make-up that we inherit from our parents, are important in the development of lupus, but the answer is much more complicated than a simple "yes". Estimates are that from four to six or more genes must be combined for a person to inherit a susceptibility to acquire lupus. It is nearly impossible to inherit all the genes necessary to develop lupus from a single parent, since an individual's genes come from both parents. This is one very important reason why it is unusual for lupus to occur in multiple generations of a family. If only some of the lupus genes are inherited, a person may not have lupus but may test positive for some of the immunologic tests, such as the antinuclear antibody (ANA). A positive ANA occurs in up to one third of healthy family members of lupus patients.
Genetic information is coded in chromosomes which are located in humans in a tiny part of the center (nucleus) of each cell. Humans have 46 chromosomes, each of which is made up of thousands of genes. Each chromosome is divided into a long and short arm. Most of the important genes in systemic lupus erythematosus are located on the short arm of chromosome #6. The genes on chromosome #6 have many complex functions. Some regulate complement components (proteins important in acute and chronic inflammation and in the formation of immune complexes). When these complement components are missing, a milder form of lupus, which usually lacks kidney involvement, may develop. Complement genes are important but they are not the whole story in the development of this form of lupus. For example, many susceptible individuals who lack these genes for complement never develop lupus at all.
Another important area on the short arm of chromosome #6 is the HLA (human leukocyte antigen) region. It is located next to the area for complement genes. The HLA area has been very thoroughly studied since it is used to match donors genetically to recipients for organ transplants. it is further divided into smaller regions called HLA-A, HLA-B, HLA-C, HLA-DR, HLA-DQ. In lupus patients there is an increased frequency of the HLA genes called Al, B8, Dr2, or Dr-3 and DQ1.
Associations between genes and diseases such as lupus are established by comparing lupus patients to a normal or "control" population. Particular HLA markers found in white lupus patients (on whom the majority of studies have focused) have not been shown to be present in black patients or Japanese patients with lupus. The reasons for these differences are not clear. There may be other as yet unknown genes or there may also be important genes on other chromosomes which play a part in making a person susceptible to developing lupus.
The newest research methods now being used to study genetics come from the field of molecular biology. They are redefining the way in which we look at the genetics of disease. When methods of molecular biology are used to study the HLA system in various diseases, we are finding that what looked like a specific HLA type, by our current standard tests, in reality is slightly different and Much more complex. This methodology should lead to new important findings, both in genetics and in lupus.
Another way of studying the genetics of lupus is by looking at families in which lupus occurs in more than one member. Familial cases are reported in approximately 10% of the lupus population. The most thoroughly studied family association is between twins. If one of a pair of identical twins (twins with exactly the same genes) has lupus, the other will develop it more than two thirds (69%) of the time. If a fraternal or non-identical twin (a twin with genes no more similar to his twin than to any other brother or sister) has lupus, the other twin has only a 5% chance of developing it. It is obvious that genetics are important, since the frequency of developing lupus is so much higher in identical twins than in fraternal twins when one of the twins already has lupus. Genetic factors cannot be the only answers, however, or susceptible identical twins would both develop lupus 100% of the time. Environmental factors, therefore, must also be important. It appears that some people are genetically predisposed to develop lupus but then must be exposed to the proper environmental triggers in order to have the disease.
In summary, heredity is involved in the development of lupus but it is rare to have more than one family member who has lupus. Much is known about the genetics of lupus, yet even more needs to be discovered. It is only through careful family studies using molecular biological techniques that the answer to the genetic riddle of systemic lupus erythematosus and the relationship between heredity and environment will be solved."
I hope this answered at least part of your questions.
Peace and Blessings
05-04-2006, 01:10 PM
Personally I think you CAN be predisposed to lupus from your genes. In my case, my dad has diabetes and just beat colon cancer. But my mom has had 5 strokes, has MS AND RA. So coming from that gene pool how could I NOT have ended up with something ya know? But my brother and my sister are both healthy. I got the short end of that particular straw LOL so I guess my answers are no I've never heard of it but that doesn't make your mom a freak but yes I think she might could have predisposed you to something like it. Has SHE been tested for Lupus? When I was dx'd I made my mom go get tested. WE already knew she had MS but she also tested positive for the RA. So if she hasn't then it might be worth it for her to just see what shows up.
i'm like that and i have lupus. they tell me it's because of my lupus. the last year that i worked i had chickenpox 7 times and measles 3 times. i was working in a preschool/ child daycare and as long as those things were going aroung the center i got them. are the sure your mom doesn't have lupus?
by the way i've never gotten to actually talk to anyone else who has had all those things multiple times like myself.
05-06-2006, 01:28 AM
Well, if she does, it's dormant... Or something... Because she is healthy... She rarely gets sick, and when she does get a cold or something it goes away quickly... Then again... I used to be that way before MY lupus, too... But, anytime she has been exposed to those illnesses she has gotten them... Me on the other hand... I had chicken pox once, got my vaccines for the other and have never had any of them again...
And I suppose there is no real way to tell if there is something in her that might make her suseptible to Lupus, too... Unless she actually gets sick...
Hmmmmm..... Tis a mystery....